https://www.vetsurgeon.org/f/clinical-questions/26640/binucleate-round-cells-on-blood-smear Hi, Looking at a blood smear from a lizard losing weight and found lots of binucleate eosinophilic round cells. There is a strong index of suspicion of multifocal neoplasia from ultrasound scan - could these be circulating neoplastic cells? Or areen-USTelligent Community 10https://www.vetsurgeon.org/thread/192143?ContentTypeID=1Fri, 02 Feb 2018 20:25:39 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:957b6a71-fa71-4cb2-b21b-a91edff08853Beats<p>Cat/dog GP vet here I&#39;m afraid.</p> <p>To my eye, they are about the same size as the mature RBCs, and I would be thinking a RBC precursor type cell most likely rather than of leukocyte lineage... but then it is a reptile...</p> <p>Not sure if would help, but NEW methylene blue staining (that&#39;s staining with the supravital stain &quot;New methylene blue&quot; rather than staining with a new bottle of the entirely different stain &quot;methylene blue&quot;) in the event you had a spare drop or two could be done and *might* give an insight?</p><div style="clear:both;"></div>