https://www.vetsurgeon.org/f/clinical-questions/26600/seizures-following-chlorambucil-in-a-cat I have a cat that was diagnosed with gi lymphoma and started on chlorambucil and pred yesterday. It was decided to use this regime as temperament not good for iv drugs. He was given 20mg per kg chlorambucil to repeat in 14 days as per this regime. en-USTelligent Community 10https://www.vetsurgeon.org/thread/191525?ContentTypeID=1Fri, 19 Jan 2018 18:50:28 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:fcf47ce7-97ac-4688-8775-bcb4b079a878Robin Grimmer<p>On questioning the owner he had had a couple of seizure like episodes before the treatment was started. He wasn&#39;t doing well so I euthanased him this evening. Thanks for your help Gerry.</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/191520?ContentTypeID=1Fri, 19 Jan 2018 13:35:54 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:ce9c1ce7-a3fb-4a76-bb45-57bb6d946fcaRobin Grimmer<p>Thanks Gerry, yes I meant 20mg per m2!</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/191519?ContentTypeID=1Fri, 19 Jan 2018 13:32:29 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:4c8e0272-6bff-4ffe-9f28-5fc2b4ba9546Gerry Polton<p>Benitah N, de Lorimier LP, Gaspar M, Kitchell BE. (2003) Chlorambucil-induced myoclonus in a cat with lymphoma. <i>Journal of the American Animal Hospital Association </i><b>39</b>, 283-287</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/191518?ContentTypeID=1Fri, 19 Jan 2018 13:31:54 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:0d6f835f-5c99-44fc-9055-2c8b324adb39Gerry Polton<p>I really hope you meant 20mg/sqm?</p> <p>Neurotoxicity is reported in cats with chlorambucil, also in people, but I have not heard of it manifesting as seizures. I haven&#39;t seen chlorambucil-associated neurotoxicity. Of course, the underlying disease is also capable of inducing neurological signs.</p> <p>Gerry&nbsp;</p><div style="clear:both;"></div>