Jejunal lymphoma

RE: Jejunal lymphoma

Gerry Polton — Wed, 10 Jan 2018 17:43:13 GMT

That's my pleasure

As a general note to all, I am sorry that I don't find time to contribute more frequently

Have a good evening

RE: Jejunal lymphoma

Beats — Wed, 10 Jan 2018 17:08:03 GMT

That's very helpful, Gerry!

Thanks so much for taking the time sharing your insights!

RE: Jejunal lymphoma

Gerry Polton — Wed, 10 Jan 2018 16:33:59 GMT

As a rule these patients perform poorly. Two published case series. Median survival times were 14d and 30d from the date of diagnosis.

My own experience is different. we can manage some of these cases relatively well but they are difficult to manage because the bowel is messed up and this has consequences for systemic health.

A further reason that they don't do well under the care of normal vets and even normal oncologists is that they are often treated with COP or CHOP and they rarely are responsive to these medications.

There isn't a stock answer to the 'how do you treat them' question. They will need supportive care that meets their individual needs. Your best bet for initial medical therapy would be a combination of L-asparaginase and cytosine arabinoside in my opinion. Once they are in an improved state of systemic health, a medium to long term cytotoxic therapy can be implemented according to analysis of the lymphoma subtype.

Short version: symptomatic care often your best bet

Gerry

RE: Jejunal lymphoma

Jenny Harris — Wed, 10 Jan 2018 16:15:37 GMT

No personal experience but I am looking back at notes from a recent-ish lecture with Ed Hall and apparently alimentary lymphomas in dogs are not good news, they usually respond poorly to therapy and there is a risk of perforation. I’ve also written down that he said he often wont treat and just palliates with steroids...

RE: Jejunal lymphoma

Beats — Wed, 10 Jan 2018 16:06:21 GMT

[quote user="roland bulkyn-rackowe"]Any immunohistochemistry on those samples?[/quote]

pending

[quote user="roland bulkyn-rackowe"]Is it a solitary mass or more extensive infiltration?[/quote]

appearance was of 3 areas 3cm-5cm in length each within the jejunum which were clearly abnormal with red, dilated appearance. Single full thickenss biopsy from middle of one of these with extensive ulceration and probable lymphoma.

[quote user="roland bulkyn-rackowe"]How do the lymph nodes, liver and spleen look?[/quote]

All unremarkable on gross appearance.

[quote user="roland bulkyn-rackowe"]I've had very poor outcomes with these cases, I'm interested to hear other's opinions.[/quote]

Agreed. I have very little experience in this area.

[quote user="Martin Atkinson"]??? Not sure where we're going with this - enlighten us.[/quote]

Enquiring of those with more experience/knowledge re up-to-date thinking in cases of jejnunal lymphoma.

RE: Jejunal lymphoma

Roland Bulkyn-Rackowe — Wed, 10 Jan 2018 13:50:41 GMT

Any immunohistochemistry on those samples? Is it a solitary mass or more extensive infiltration? How were the biopsies taken? How do the lymph nodes, liver and spleen look? I've had very poor outcomes with these cases, I'm interested to hear other's opinions.

RE: Jejunal lymphoma

Martin Atkinson — Wed, 10 Jan 2018 09:58:35 GMT

??? Not sure where we're going with this - enlighten us.