Type III Cysteinuria in an English Bulldog

RE: Type III Cysteinuria in an English Bulldog

gerard mclauchlan — Tue, 07 Nov 2017 14:53:21 GMT

Association between cystine urolithiasis and neuter status of dogs within the UK

Authors

First published: 5 July 2017Full publication history
DOI: 10.1111/jsap.12707 View/save citation
Cited by (CrossRef): 0 articles Check for updates

Abstract

Objectives

The objectives of the study were to examine the association between diagnosis of cystine urolithiasis and entire versus neutered status in male dogs and whether the strength of association varies among breeds.

Materials and Methods

A previously reported canine urolithiasis database was used, documenting all urolith submissions to Hill's Pet Nutrition UK over a 10-year period. Uroliths were classified as cystine or non-cystine, and only male dogs with known neuter status were included in the analysis. Breeds of dog (and an additional crossbreed group), for which there was a minimum of 10 cystine urolith submissions, were analysed individually, with all other breeds combined together to form a reference group. Results were analysed using chi-squared and Fisher's exact tests. Logistic regression was used to assess associations between breed and neuter status and formation of cystine calculi.

Results

In multiple breeds, dogs with cystine uroliths were significantly more likely to be entire than dogs forming other types of urolith. Being an entire male, regardless of breed, was associated with an increased risk of cystine urolithiasis (odds ratio=4·5; 95% confidence interval: 3·22 to 6·37; P<0·001).

Clinical Significance

Increased odds of cystine formation in entire dogs supports further investigation of castration as a method to prevent cystine urolithiasis.

RE: Type III Cysteinuria in an English Bulldog

Anthony Dennison — Tue, 07 Nov 2017 14:45:59 GMT

[quote user="gerard mclauchlan"]

Hi Anthony.

androgen influence suspected in many breeds but has been showen in English Bulldogs. I recommend castration in all these cases. Recent JSAP (I think) looking at neutering status in these dogs

thanks

gerard

[/quote]

Excellent, I'll have a look for that!

RE: Type III Cysteinuria in an English Bulldog

nikki — Mon, 06 Nov 2017 22:53:04 GMT

Had a case in an English Bulldog this week. Needed a cystotomy and urethrotomy. Was also neutered at same time. Currently waiting for stone analysis.

RE: Type III Cysteinuria in an English Bulldog

Julie Innes — Mon, 06 Nov 2017 21:49:05 GMT

That's good to know! I have had a similar case in a male entire bulldog and another in a French bulldog. Next time I see them I will definitely mention castration. Thanks!

RE: Type III Cysteinuria in an English Bulldog

gerard mclauchlan — Mon, 06 Nov 2017 20:14:16 GMT

Hi Anthony.

androgen influence suspected in many breeds but has been showen in English Bulldogs. I recommend castration in all these cases. Recent JSAP (I think) looking at neutering status in these dogs

thanks

gerard