Trimethoprim/sulpha- no longer available?

RE: Trimethoprim/sulpha- no longer available?

Yantha Smyth — Sun, 19 Nov 2017 09:48:26 GMT

i looked on medicines.org, and as some one else mentioned above, there are co-trimoxazole tablets and suspension available on the human side

paediatric susp 200/40mg/5ml

adult susp 400/80mg/5ml

400/80mg and 800/160mg tablets

the newish animal licensed sulfatrim seems to be totally impractical for anything other than the small creatures it was made for

RE: Trimethoprim/sulpha- no longer available?

Lindsey Edwards — Fri, 17 Nov 2017 16:07:43 GMT

According to our norbrook rep norodine is no longer to be produced but there are still some stocks available.

RE: Trimethoprim/sulpha- no longer available?

Caroline Allen — Wed, 15 Nov 2017 23:22:43 GMT

I heard different things from different people about Noradine but the rep I saw today thought it was still available. She is checking but I was also told they are all made at the same factory, that has now stopped making it.

RE: Trimethoprim/sulpha- no longer available?

Rob Loxley — Wed, 15 Nov 2017 21:18:33 GMT

[quote user="Rob Davis"]Sulfatrim oral drop, licensed for rabbits, pigeons and bearded dragons (?!), so according to cascade, should presumably be using this ahead of any human preparations...[/quote]

For a big dog I'd argue the volumes are impractical?

RE: Trimethoprim/sulpha- no longer available?

Rob Davis — Wed, 15 Nov 2017 17:47:39 GMT

Sulfatrim oral drop, licensed for rabbits, pigeons and bearded dragons (?!), so according to cascade, should presumably be using this ahead of any human preparations...

RE: Trimethoprim/sulpha- no longer available?

Lindsey Edwards — Wed, 15 Nov 2017 17:20:43 GMT

norodine is no longer in production

RE: Trimethoprim/sulpha- no longer available?

Andrei Uricaru — Mon, 13 Nov 2017 20:53:14 GMT

Hi Caroline,

NOrodine 80 from NVS.

RE: Trimethoprim/sulpha- no longer available?

Caroline Allen — Sun, 12 Nov 2017 17:29:21 GMT

I know, so annoying. Yes, the human one is Trimetheprim only, I'll look into if it will still work, it doesn't seem very clear.

RE: Trimethoprim/sulpha- no longer available?

Caroline Allen — Sun, 12 Nov 2017 17:27:10 GMT

Trimacare is about to disappear unfortunately. Will take a look at Septrin. Thanks

RE: Trimethoprim/sulpha- no longer available?

Scarlett Creasey — Fri, 03 Nov 2017 09:32:07 GMT

[quote user="Michael Woodhouse"]

Do scouring calves require antibiotics?

[/quote]

Well probably a tangent... A group of us recently had to do a critical literature review of antibiotics in scouring calves <3wks old. There is a lot of research into the area but the outcomes we found were that antibiotics have no effect to morbidity rate in systemically well calves but certain parenteral ABs did reduce morbidity in groups of systemically unwell calves attributed to either primary or secondary e coli overgrowth and bacteraemia. I think the only ABs with enough evidence to support were potentiated amoxicillin and TMPS

Goes along with fluids and supportive care ofc.

RE: Trimethoprim/sulpha- no longer available?

Michael Woodhouse — Fri, 03 Nov 2017 00:22:21 GMT

[quote user="Scarlett Creasey"]Not good for farm med either as it is a good choice for severe calf scour[/quote]

Do scouring calves require antibiotics?

RE: Trimethoprim/sulpha- no longer available?

Scarlett Creasey — Thu, 02 Nov 2017 15:12:41 GMT

[quote user="Julie Innes"]

At the moment we have some massive tablets that I'm guessing were designed for calves, so we're hanging onto them and divvying them up!

There is a human preparation, but I believe it is trimetheprim only- anyone know if that makes a big difference?

[/quote]

The sulfonamide is potentiated and I think the two work together synergistically so there is a lower MIC and it broadens the spectrum that are susceptible. I think I read somewhere about high bacterial resistance to trimethoprim alone (especially for e coli??) but they still seem to use it for cystitis in humans.

Not good for farm med either as it is a good choice for severe calf scour

RE: Trimethoprim/sulpha- no longer available?

Rob Loxley — Thu, 02 Nov 2017 14:57:08 GMT

[quote user="Julie Innes"]Really annoying, as I also use it for urinary and prostate issues- I don't really want a dog on really broad spectrum antibiotics for 4-6 weeks, and it was so cheap and cheerful[/quote]

For urinary antibiotics, often plain amoxicillin (eg Amoxibactin) will do just fine and much cheaper than synulox.
If you go off down the cascade, you can buy human generic Co-Trimoxazole tabs 800/160mg for about 30p each

RE: Trimethoprim/sulpha- no longer available?

Julie Innes — Thu, 02 Nov 2017 09:24:48 GMT

Really annoying, as I also use it for urinary and prostate issues- I don't really want a dog on really broad spectrum antibiotics for 4-6 weeks, and it was so cheap and cheerful . At the moment we have some massive tablets that I'm guessing were designed for calves, so we're hanging onto them and divvying them up!

There is a human preparation, but I believe it is trimetheprim only- anyone know if that makes a big difference?

RE: Trimethoprim/sulpha- no longer available?

Clive Ansell — Wed, 01 Nov 2017 18:34:10 GMT

Pity, I use a lot of it.

Bull Mastiff today; haematuria, huge prostate, owners no money so declined investigation, castration or Ypozane, pot full of TMS and off you go. PDSA INB, if they'll take them.

RE: Trimethoprim/sulpha- no longer available?

Debbie Harvey — Wed, 01 Nov 2017 16:54:59 GMT

Trimacare 80mg (Animalcare) is currently available from Centaur, we also use Septrin off licence.

RE: Trimethoprim/sulpha- no longer available?

Evelyn Barbour-Hill — Wed, 01 Nov 2017 15:19:21 GMT

[quote user="Marie Kubiak"]

[quote user="Evelyn Barbour-Hill"]

[quote user="Marie Kubiak"]What about sulfatrim suspension?[/quote]

Tastes awful.

[/quote]

Personal observation or from patient reaction?

[/quote]

Both!

RE: Trimethoprim/sulpha- no longer available?

Marie Kubiak — Wed, 01 Nov 2017 14:01:34 GMT

[quote user="Evelyn Barbour-Hill"]

[quote user="Marie Kubiak"]What about sulfatrim suspension?[/quote]

Tastes awful.

[/quote]

Personal observation or from patient reaction?

RE: Trimethoprim/sulpha- no longer available?

Evelyn Barbour-Hill — Wed, 01 Nov 2017 13:43:20 GMT

[quote user="Marie Kubiak"]What about sulfatrim suspension?[/quote]

Tastes awful.

RE: Trimethoprim/sulpha- no longer available?

Marie Kubiak — Wed, 01 Nov 2017 13:02:39 GMT

What about sulfatrim suspension? Off licence and inconvenient dosing for larger animals though..