persistently high UPC with normal bloods

RE: persistently high UPC with normal bloods

Avril Mc Ginn — Sun, 22 Oct 2017 20:54:50 GMT

does the USG of 1.012 point more towards a renal rather than a post-renal issue?

serial USG and quantify water intake to confirm the USG, if persistently around this level then SDMA?

Consider Cushings as a cause of raised UPC but usually would expect a slightly higher USg with cushings? UCCR to rule out?[quote user="Anthony Dennison"]

Colleague has asked for some help on a case he's dealing with at the moment. Dog is clinically normal, had a urine sample done and had a USG of 1.012. Bloods showed slightly raised urea, creatinine well WNL, rest of bloods fine. UPC was really high, at about 4.

Since then all bloods have been normal. Urine sediment unremarkable. Nothing cultured on urine culture. Ultrasound scan unremarkable.

Dog is fine in itself, but UPC isn't dropping below 2. I've suggested checking SDMA, but if the bloods are normal I'm assuming it may be a post renal issue?

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RE: persistently high UPC with normal bloods

Bill Nolan — Sat, 21 Oct 2017 14:32:53 GMT

+1 for primary glomerulonephropathy. Could always start on brnazepril/telmisartan and monitor response if owners not keen for referral and inaging/renal biopsy

RE: persistently high UPC with normal bloods

Dinu Catilina — Fri, 13 Oct 2017 18:42:53 GMT

What breed of dog is it? Some breeds that have juvenile glomerulonephropathy can have an elevated UPC for years before they actually get in kidney failure and you see changes in bloods.

I don't find SDMA helpful I had high in normal dogs and normal in dogs with renal failure. I wouldn't trust it