Melatonin implant

RE: Melatonin implant

Lindsey Edwards — Sat, 07 Oct 2017 20:27:55 GMT

I have found the same responses to delvosterone previoulsy administered to cats - ie prolonged interruptions to cycling, a pyometra (yes - in a cat) and have also encountered mammary tumours in treated cats. It is not a drug I use or stock for these reasons and have only the owners recollections of having had shots to prevent heat in the case of the pyo.

As all options are going to be off license this will have to form part of the discussion in all cases in relation to future breeding. My advice to all potential breeders is to NEVER interfere with the normal cycle and to breed at first age appropriate cycle. I would prefer to use the smaller supreolorin and remove as soon as possible to limit long term impact if owner is insistent on using something under the caution that future heats and fertility may be affected

RE: Melatonin implant

Marie Kubiak — Sat, 07 Oct 2017 20:12:50 GMT

[quote user="villagevet"]suprerolorin implant (comes in pack of 2!)[/quote]

I would be very cautious about using deslorelin- it has been found in big cats to permanently disrupt cycling. If used off licence in a breeder's cat there could be an unpleasant conversation later on if the cat never bred again!

I have used delvosteron (again big cats not domestic) to end/suppress oestrus successfully. Is there any data in domestic cats?

Marie

RE: Melatonin implant

Kate Richardson — Sat, 07 Oct 2017 20:10:30 GMT

[quote user="villagevet"]

suprerolorin implant (comes in pack of 2!)

[/quote]

Thankyou, this is an option I have put to her as it is the most effective option available but can last for over 2 years, although can be removed if placed strategically in the inguinal area

RE: Melatonin implant

Lindsey Edwards — Sat, 07 Oct 2017 19:56:37 GMT

suprerolorin implant (comes in pack of 2!)

RE: Melatonin implant

Kate Richardson — Sat, 07 Oct 2017 10:17:09 GMT

[quote user="Michael Woodhouse"]

I suspect your cat will come out of heat very soon whatever you do.

[/quote]

I would have thought so too but apparently not last year!

RE: Melatonin implant

Michael Woodhouse — Fri, 06 Oct 2017 12:27:49 GMT

[quote user="Kate Richardson"]Michael Woodhouse do you use these?[/quote]

No, sorry. It's the pack size of 50 that knocks the idea on the head, very hard to fit it to flock sizes. I have some people who'd use it otherwise.

I suspect your cat will come out of heat very soon whatever you do.

RE: Melatonin implant

Iain Richards — Fri, 06 Oct 2017 08:05:39 GMT

In Cumbria and not in practice!

Thanks for the explanation. Won't the season just stop soon anyway?

RE: Melatonin implant

Kate Richardson — Thu, 05 Oct 2017 17:39:56 GMT

Excuse my laziness, sections copied and pasted from an article in JSFM. I have no personal experience of it in cats. It seems to be variable in effectiveness and duration. Breeder is interested in using it, so am researching options for her. Thanks for the price info etc. Would suggest implanting under sedation methinks!

"Cats are seasonally polyestrous (they cycle several times during their breeding season) and are described as long-day breeders because endogenous melatonin negatively regulates estrous cyclicity. Exogenous melatonin administered parenterally also suppresses ovarian activity in cats"

"The domestic cat is a seasonal long-day breeder, meaning that reproductive activity is influenced by photoperiod. In the northern hemisphere, ovarian activity typically ceases in October under decreasing photoperiod and resumes in January with increasing photoperiod.¹⁶ Reducing the photoperiod to 8 h of light inhibits folliculogenesis in queens.¹⁷ Cats cease estrous cyclicity immediately when the photoperiod is reduced from 14 h to 8 h, and estrous cycles resume in 12–26 days (15.6 ± 0.5 days) after the photoperiod is increased from 8 h to 14 h.^17,18 The immediate suppressive effects of melatonin on follicular growth may be mediated through a cytoplasmic receptor,¹⁹ which could directly interfere with estrogen synthesis. Melatonin has also been shown in one study to decrease the amount of luteinizing hormone (LH) released in response to mating.²⁰ However, 67% of cats followed in the study ovulated despite changes in LH.^20"

"Decreasing photoperiod is related to high endogenous melatonin concentrations, which are then followed by decreased sexual activity. Exogenous melatonin can be used to mimic this situation. Either oral or parenteral administration of exogenous melatonin or melatonin receptor agonists will suppress feline reproductive function."

Do you use it yourself? Any chance you are near Bath?!!!

Michael Woodhouse do you use these?

RE: Melatonin implant

Iain Richards — Thu, 05 Oct 2017 12:41:55 GMT

Can you run the way it suppress oestrous for me by me please. We use it in sheep to bring forward mating as melatonin rises with decreased day length. How does it affect cats? Approx £200 for a box of 50 and £35 for the implanter, so well within the budget of a pedigree cat breeder! It's a chunky needle though.