Methimazole ear gel .

RE: Methimazole ear gel .

Sarah Keir — Wed, 05 Jul 2017 09:14:45 GMT

Thyronorm did not a license for use in the Netherlands due to health risk of those administering, they would have to put on such long and extensive risk analysis...this is directly from Norbrook themselves.

RE: Methimazole ear gel .

Martin Atkinson — Wed, 05 Jul 2017 09:04:17 GMT

All this begs a question about how clients administer methimazole tablets when they can't pill the cat. AFAIA carbimazole can't be crushed up as it alters the bio-availability but the reason not to crush methimazole is because of the public health risk. I tell clients off the record that so long as they are careful and the tablets are not handled by pregnant (or might be) women it is safe to crush methimazole but the dispensing label still tells them not to crush them Considering the risks we've highlighted in the previous posts with the gel then this doesn't seem unreasonable and it allows a lot more people to be able to easily and affordably treat their cats.

RE: Methimazole ear gel .

Thomas Johnson — Wed, 05 Jul 2017 09:03:51 GMT

[quote user="Simon Neuhoff"]

Presumably in tiny quantities though! Would there be any issues with humans absorbing such tiny amounts? Suspect not.

I don't use it in households where there are very young kids cuddling the cat.

[/quote]

I don't know how big the risks are, but I do worry about this quote from the Felimazole data sheet:

"As thiamazole is a suspected human teratogen, women of child-bearing age and pregnant women should wear gloves when handling litter of treated cats. Pregnant women should wear gloves when handling the product."

RE: Methimazole ear gel .

Simon Neuhoff — Wed, 05 Jul 2017 08:35:26 GMT

Presumably in tiny quantities though! Would there be any issues with humans absorbing such tiny amounts? Suspect not.

I don't use it in households where there are very young kids cuddling the cat.

RE: Methimazole ear gel .

Sarah Keir — Mon, 03 Jul 2017 13:48:46 GMT

It also showed it was spread all over the owners house. Not the kind of drug that I would like to be lying around my household surfaces.

RE: Methimazole ear gel .

Martin Atkinson — Sat, 01 Jul 2017 10:51:12 GMT

[quote user="Thomas Johnson"]Surely this just shows that the dye isn't absorbed through the skin, not whether the drug is absorbed through the skin or not?[/quote]That is a good question. I think the point is that we are instructed to apply to the underside of the pinna to avoid the cat licking it off but clearly they are cleaning it with their paws then licking it off them and re-distributing it over their coat. It all revolves around how soon they groomed, how bound to the vehicle the dye is and how fast it is absorbed. Clearly it is impractical to use a Buster collar every day. But it does make it rather less than straightforward.

RE: Methimazole ear gel .

Thomas Johnson — Sat, 01 Jul 2017 10:32:08 GMT

[quote user="Martin Atkinson"]Incidentally some research has shown that although it is in theory adsorbed transdermally, when dye was put in it the colour appeared all over the cat's coat thus showing that it was grooming it off the ears with its paws and some of the adsorption at least was oral. This then begs the question: why just put it on the underside of the pinnas, why not just stick it anywhere and let the cat lick it off?[/quote]

Surely this just shows that the dye isn't absorbed through the skin, not whether the drug is absorbed through the skin or not?

RE: Methimazole ear gel .

Martin Atkinson — Sat, 01 Jul 2017 10:21:02 GMT

I'd apply it according to client compliance and repeat T4 testing. I had one cat which even when the owner plastered every bit of it's pinnas still didn't have enough therapeutic effect once daily.

Incidentally some research has shown that although it is in theory adsorbed transdermally, when dye was put in it the colour appeared all over the cat's coat thus showing that it was grooming it off the ears with its paws and some of the adsorption at least was oral. This then begs the question: why just put it on the underside of the pinnas, why not just stick it anywhere and let the cat lick it off?

RE: Methimazole ear gel .

Glenn Hodgson — Fri, 30 Jun 2017 23:46:45 GMT

Twice here. It is great ( but relatively >£)

Less need for it with norbrooks liquid being available.

RE: Methimazole ear gel .

Catriona MacIntyre — Fri, 30 Jun 2017 21:37:51 GMT

I think all our current cases are once daily. We also advise clients to alternate which ear they medicate.