DDAVP nasal spray - administration ??

RE: DDAVP nasal spray - administration ??

Rob Loxley — Thu, 08 Jun 2017 23:51:19 GMT

[quote user="Allison Gleadhill"]Tablets not available last time I looked[/quote]

We had a dog (recently PTS) on desmopressin, sourced from Munro Vet Supplies:

Desmopressin (DDAVP) 0.2mg Tablets	Desmo02	30	£16.25
Desmopressin (Generic Desmospray) Nasal Spray 10mcg	Desmo116	6ml	£34.50

RE: DDAVP nasal spray - administration ??

Allison Gleadhill — Thu, 08 Jun 2017 18:47:08 GMT

Tablets not available last time I looked. Have a cat with central DI, could only get spray which we squirt into lick-e-Lix then cat eats it. Still low u so but the excess urination is within what owner can tolerate So some response.

RE: DDAVP nasal spray - administration ??

shanley barber — Thu, 08 Jun 2017 12:34:09 GMT

Thanks all, just to be certain, is it pretty straight forward to open the nasal spray bottle? It doesn't look that easy.......

Thanks,

Shanley

RE: DDAVP nasal spray - administration ??

Andrew Kent — Wed, 07 Jun 2017 19:33:41 GMT

[quote user="Stefano Zago"]

Hi Shanley

Centaur has DDAVP nasal drops 0.1mg/ml.

Stefano

[/quote]

Maybe drops are available again then - worth looking into.

[quote user="robloxley"]

[quote user="Andrew Kent"]nasal spray or use oral tablets (although the absorption of the latter can be variable).[/quote]

Is it best to avoid the tablets, or just that the dose may vary animal to animal?

[/quote]

The problem with the tablets is that there seems to be a lot of individual variation - some dogs will be well controlled on drops and not at all on tablets, or require very high doses in comparison with tablets. Plus sometimes there is day to day variation in control with tablets.

We do sometimes use them (usually if the drops prove impossible to administer) but prefer not to.

Also quite often we are trialling therapy to see if there is a response, so if we use the oral route we can never be sure if lack of response is due to wrong diagnosis or poor absorption.

[quote user="Thomas Johnson"]I also found that the tablets were much more expensive than the spray when I looked into it last year when the drops were discontinued.[/quote]

I agree this seems to be the case.

Andy

RE: DDAVP nasal spray - administration ??

Thomas Johnson — Wed, 07 Jun 2017 19:07:09 GMT

[quote user="robloxley"]

[quote user="Andrew Kent"]nasal spray or use oral tablets (although the absorption of the latter can be variable).[/quote]

Is it best to avoid the tablets, or just that the dose may vary animal to animal?

[/quote]

I also found that the tablets were much more expensive than the spray when I looked into it last year when the drops were discontinued.

RE: DDAVP nasal spray - administration ??

Rob Loxley — Wed, 07 Jun 2017 17:01:06 GMT

[quote user="Andrew Kent"]nasal spray or use oral tablets (although the absorption of the latter can be variable).[/quote]

Is it best to avoid the tablets, or just that the dose may vary animal to animal?

RE: DDAVP nasal spray - administration ??

Stefano Zago — Wed, 07 Jun 2017 16:10:35 GMT

Hi Shanley

Centaur has DDAVP nasal drops 0.1mg/ml.

Stefano

RE: DDAVP nasal spray - administration ??

Andrew Kent — Wed, 07 Jun 2017 15:51:57 GMT

Hi Shanley,

Yes you will likely need to transfer into a different bottle. They used to produce it in a dropper bottle but I believe this has been discontinued (or is at least not currently available) so you can transfer the spray into a dropper bottle, use it as a nasal spray or use oral tablets (although the absorption of the latter can be variable).

Andy