Anal furunculosis and carprofen

RE: Anal furunculosis and carprofen

Julian Earl — Fri, 05 May 2017 12:24:40 GMT

Yes Martin, but as my attempts at surgery for this seemed doomed to fail I stick to medical means. Diathermy was no better than a plain old scalpel and flushing etc. I wouldn't even try surgery now having seen the response to anti-inflammatory regimes.

RE: Anal furunculosis and carprofen

Martin Atkinson — Fri, 05 May 2017 12:04:35 GMT

[quote user="Julian Earl"]The only medication that I found helped, and I have to say, did so dramatically in many cases was a combination of Metronidazole, with that taboo-drug prednisolone,[/quote]That was the treatment of choice combined with some surgery sharp/cryo/electro or otherwise until cyclosporin came along. There was a time when it was suggested using ketoconazole in combination to reduce the cost of the cyclosporin but that seems to have died a death. Surgery doesn't get a look in at referral centres at the moment but I wonder how long it will be before the laser boys get in on the act.

RE: Anal furunculosis and carprofen

Julian Earl — Fri, 05 May 2017 10:36:48 GMT

The only medication that I found helped, and I have to say, did so dramatically in many cases was a combination of Metronidazole, with that taboo-drug prednisolone, so very potent immunosuppressive combination, combined usually with a hypoallergenic diet. I had several cases clear up completely on this regime. I think I learnt if from a CPD- course at sometime that suggested the condition is bsased on the unusual immune system of GSDs and not from anal gland disease etc.

RE: Anal furunculosis and carprofen

Martin Atkinson — Thu, 04 May 2017 15:24:41 GMT

Of course it could nothing to do with any of it but the homeopathy they were secretly giving it.

Given the phenotype it would seem most likely to be coincidental but the link appears to be there so I would report it. Who knows it may lead to further investigation.

RE: Anal furunculosis and carprofen

Rob Davis — Thu, 04 May 2017 15:10:30 GMT

Update: I have reexamined this dog today and the anal furunculosis has now almost totally resolved. The owner has also stopped using cyclavance in the last 2 weeks and there has been no deterioration (still using tacrolimus topically). The anal furunculosis started 2months after starting carprofen, was present for around 1 year, waxing and waning but never resolving despite cyclavance, tacrolimus and occasional courses of clindamycin, and has now all but completely resolved within 6 weeks of stopping carprofen. It may be coincidence, but....

Should this be reported via SARRS?

RE: Anal furunculosis and carprofen

Catriona MacIntyre — Tue, 14 Mar 2017 22:52:58 GMT

Argh frikkin technology!

RE: Anal furunculosis and carprofen

Andrew Mellor — Tue, 14 Mar 2017 09:20:06 GMT

kill or cure

RE: Anal furunculosis and carprofen

Niall Taylor — Tue, 14 Mar 2017 06:31:57 GMT

[quote user="Catriona MacIntyre"]We switched to a plain carcinogen tablet...[/quote]

Harsh...

RE: Anal furunculosis and carprofen

Catriona MacIntyre — Mon, 13 Mar 2017 21:53:22 GMT

Was it a palatable preparation?

I have one patient that the owner was convinced that Rimadyl made its skin worse. We switched to a plain carcinogen tablet and it did seem much better. Food sensitivity?

RE: Anal furunculosis and carprofen

Jill Butterworth — Mon, 13 Mar 2017 21:41:38 GMT

It's quite a significant co-incidence...I think we vets habitually under report side effects compared to our human counterparts.

It's surely worth trying something else, GSD's have strange immune systems .

RE: Anal furunculosis and carprofen

Richard Carter — Mon, 13 Mar 2017 18:30:10 GMT

anti-inflammatory reducing healing capacity by depressing PG? Just thinking on same basis as not wanting to use NSAIDs for git ulceration?

Not heard of a direct case on NSAID re anal furunculosis but then we also use cortisone to reduce fibrosis for eg in pulmonary conditions and we know that healing will be delayed in operations by suppressing inflammation.