Thiamine Deficiency

RE: Thiamine Deficiency

Michael Woodhouse — Sun, 05 Mar 2017 15:21:34 GMT

I see now. I was taking it far too literally and trying to see what Intralipid added to the treatment of B1 deficiency.

RE: Thiamine Deficiency

mariette asselbergs — Sun, 05 Mar 2017 12:55:07 GMT

[quote user="Michael Woodhouse"]

Mariette, why Intralipid? B1 is water soluble so should be harmless if not needed.

We see Polioencephalomalacia/CCN all the time in ruminants and it's not hard to treat (although initiated by a different route). Not sure I would have considered it in a cat as a DDx

[/quote]

Because intralipid treats other neurotoxins (if lipid soluble) effectively and safely and from the symptoms you cannot be sure it is CNN (as is extremely rare in cats and in these cases apparently caused by exclusive feeding on one brand of dry food.

Mariette

RE: Thiamine Deficiency

Beats — Sat, 04 Mar 2017 18:58:54 GMT

[quote user="Michael Woodhouse"]Mariette, why Intralipid? B1 is water soluble so should be harmless if not needed.[/quote]

I think Mariette is thinking those signs could be eg permethrin toxicity, which in some circles is treated with intralipid. Her question hence is if I don't know whether a toxin treatable by intralipid or thiamine deficiency, and I give my preferred treatments for both, could the intralipid have any negative consequences should the cat be suffering from thiamine deficiency? (If I've understood correctly)

RE: Thiamine Deficiency

Michael Woodhouse — Sat, 04 Mar 2017 18:05:01 GMT

Mariette, why Intralipid? B1 is water soluble so should be harmless if not needed.

We see Polioencephalomalacia/CCN all the time in ruminants and it's not hard to treat (although initiated by a different route). Not sure I would have considered it in a cat as a DDx

RE: Thiamine Deficiency

mariette asselbergs — Sat, 04 Mar 2017 09:00:47 GMT

Since it is almost impossible to diagnose quickly with certainty, is there any contraindication to put these cases on intralipid as well as giving them thiamine and change food?

Mariette

RE: Thiamine Deficiency

Kate Richardson — Fri, 03 Mar 2017 08:13:10 GMT

Courtesy of Angie Hibbert at Langford:

The cases known about were after a few weeks (3-6), but it could depend also on GI and liver function. Have you seen the veterinary neurology pages on faecbook? We've shared them via the Langford Vets twitter and facebook feed, but hopefully this link will work https://www.facebook.com/search/top/?q=veterinary%20neurology. Laurent Garosi has put a nice video and description of the case he saw and there is a great Q& A sheet on thiamine deficiency.

RE: Thiamine Deficiency

grumpyoldman — Thu, 02 Mar 2017 23:16:00 GMT

Does it have the classic strip of hyper reflectivity across the tapetum ?

RE: Thiamine Deficiency

Linda Filshie — Thu, 02 Mar 2017 15:29:37 GMT

I've read as little as 3-4 weeks.

RE: Thiamine Deficiency

Bob Russell — Thu, 02 Mar 2017 15:15:55 GMT

A complete disaster especially as it is not particularly high on the differential diagnosis list for cats on a commercial pet food.

Not sure how long (or short) a period they have to be on this food before symptoms show up.