Replacement for Fosamax

RE: Replacement for Fosamax

Rob Loxley — Thu, 19 Jan 2017 19:02:27 GMT

Do we have evidence comparing different bisphosphonates in dogs; I've always used alendronic acid which is very cheap but am I missing better gains to be had elsewhere?-

RE: Replacement for Fosamax

Emily Rainbow — Thu, 19 Jan 2017 09:53:52 GMT

I've got a prostatic carcinoma dog with spinal/pelvic mets who is doing amazingly well comfort wise following pamidronate infusion at the RVC. Slight improvement on Previcox but drastic changes after starting it.

RE: Replacement for Fosamax

Lindsey Edwards — Fri, 13 Jan 2017 20:55:49 GMT

amputation of affected forelimb if severe pain non-responsive to a cocktail of analgesics?

RE: Replacement for Fosamax

Stephen Courtney — Wed, 11 Jan 2017 19:03:00 GMT

We use bonefos (spp ?) at our hospital

the use of bisphosphonates reduces osteoclastic activity therefore reduces both pain and morbidity, and extends survival time, in many bone related cancers. Widely used in human medicine.

RE: Replacement for Fosamax

Aine Seavers — Wed, 11 Jan 2017 03:29:11 GMT

No luck, only generics are also 70mg slow release. the horse is 400mg and I only need 40. Has there been any work on amadatine along with gabapentin and metacam-The BSAVA formulary shows no contra-indications, just wondering if any issues I should be aware of. Can you stop and start it also on an ad need basis?

RE: Replacement for Fosamax

Aine Seavers — Wed, 11 Jan 2017 03:12:58 GMT

Thanks Wren and Andrew, will chase it down this week as back at work, very much appreciate the replies and info.

RE: Replacement for Fosamax

Andrew Kent — Mon, 09 Jan 2017 09:19:31 GMT

You could add amantadine as another analgesic.

Radiotherapy can also help with palliation of pain from osteosarc.

But the BNF lists about 10 different generics of alendronate and we have been using those over the branded for some time. I see no reason these shouldn't exist over there as well?

Andy

RE: Replacement for Fosamax

Wren — Mon, 09 Jan 2017 08:56:06 GMT

I know nothing about canine applications, but if you are looking for a readily available bisphosphonate we very regularly use Os Phos (clodronate, Dechra) and Tildren/Equidronate (tiludronate, CEVA) in horses. Might be worth researching if you can't get what you are looking for?

RE: Replacement for Fosamax

Aine Seavers — Mon, 09 Jan 2017 08:26:37 GMT

The chemist today led myself and client to the impression there was no generic here as no demand-I will chase it down further. In the event there is none-any other meds?

Huge thanks Aine

RE: Replacement for Fosamax

Andrew Kent — Mon, 09 Jan 2017 08:10:40 GMT

Hi Aine,

There are a huge number of generic versions of 10mg alendronic acid (alendronate) which, as far as I know, are still available?

Andy