seizures following phenylpropanolamine therapy

RE: seizures following phenylpropanolamine therapy

Martin Atkinson — Thu, 29 Sep 2016 09:07:08 GMT

[quote user="Francisco Gomez"] I wonder what the BP was and if that had any relevance but the client wasn't keen in further testing and just wanted to take their dog home that day.[/quote]It had occurred to me that as phenylpropanalamine is potentially cardiotoxic this and we have not measured BP (getting the owner to have any regular monitoring is a challenge) it might have been syncope due to hypotension (albeit the data sheet says hypertension is more likely) or an arrhythmia but what she described was more seizure like than cardiac related.

It has been reported to the VMD as an adverse reaction.

RE: seizures following phenylpropanolamine therapy

Francisco Gomez — Thu, 29 Sep 2016 08:29:52 GMT

I have - in an elderly setter I think it was, the dog had a clear urea/crea/alkp/alt/glu blood panel and went to develop a couple of seizures the same night they started the drug. Of course it was discontinued immediately and filed as reaction to VMD. It happened several months ago and the dog never had seizures again (still our client). I wonder what the BP was and if that had any relevance but the client wasn't keen in further testing and just wanted to take their dog home that day.

RE: seizures following phenylpropanolamine therapy

Stephen Courtney — Wed, 28 Sep 2016 22:25:21 GMT

You will see soon enough if the seizures recur... i think highly likely the urilin is a red herring.

I have developed fondness for incurin as the once daily tiny tablet is so much easier than nasty liquids 2-3 times a day