https://www.vetsurgeon.org/f/clinical-questions/24669/peripheral-polyneuropathy-cushing I am currently seeing a 10 year old yt with symptoms of severe peripheral polyneuropathy (flaccid paralysis, hypotonia, hyporeflexia all 4 limps and decreased eyelid reflexes, now also showing signs of dyspneu). To make a long story short: ultrasounden-USTelligent Community 10https://www.vetsurgeon.org/thread/163456?ContentTypeID=1Thu, 04 Aug 2016 07:26:43 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:9750fa1d-1383-4b35-a0e9-3522f3d293e0ilanit<p>Thank you for your searchings. I really appreciate it.</p> <p>There&#39;s no sign of thymoma on chest x-ray.</p> <p>Either way things don&#39;t look very good for this dog unfortunately :(</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/163448?ContentTypeID=1Wed, 03 Aug 2016 23:29:13 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:adb78880-d4b5-47ea-89d6-88146b655844Virginia Campbell<p>What a strange case. Poor dog. I have never seen Cushing&#39;s do this; mind you Cushings can do all sorts of weird....</p> <p>I did a VIN search for you; couldn&#39;t find much. There was a case discussion about a Cushingoid labrador with severe muscle atrophy in a front leg and polyneuropathy that went off its legs. They got the Cushings under control (hair started growing back etc) but the polyneuropathy did not resolve and the dog never got up. Case ended when it got an osteosarc on femur and euthanased. One of the contributors to discussion mentioned some research to suggest that polyneuropathy in Cushingoid dogs was not related to circulating cortisol levels but likely caused by some other mechanism, which would explain why the dog didn&#39;t improve despite decent control of cortisol with meds (either that or polyneuropathy wasn&#39;t caused by Cushings). I couldn&#39;t find any references to polyneuropathy in Cushings dogs which had responded to treatment so don&#39;t know how long it would likely take if it was going to work sorry.</p> <p>In hopes of finding another fixable problem I looked up hypothyroid polyneuropathy in case the dog is unfortunate enough to have two endocrine diseases. Unfortunately they reckoned it&#39;s slow to respond to soloxine- up to 6 weeks- and some don&#39;t respond at all due to demyelination. So I guess diagnosis would be a pain given that total T4 is almost certainly going to be low, and who knows what all the other thyroid panel stuff would be doing, and you can&#39;t just give it a couple of days of soloxine as a test and expect it to take up its bed and walk.&nbsp;</p> <p>As far as paraneoplastic syndromes are concerned- search threw up list of results for myaesthenia gravis secondary to thymoma, and some reports of metastatic thymoma including to liver.</p> <p>In short, bummer. Sorry I haven&#39;t been more use! Hopefully somebody else who has seen this or knows more about endocrinology will be along soon.&nbsp;</p><div style="clear:both;"></div>