Severe Canine oral papillomavirus

RE: Severe Canine oral papillomavirus

Kara Gibson — Mon, 03 Apr 2017 13:52:41 GMT

Unfortunately the dog was euthanased as the lesiosn were worsening and he had infections in his mouth and was struggline to eat. I seriously suspect he had an underlying tumour or other cause of immunosupression. This dog was in a different league to the one in your photo, he had huge lesions over all of his lips, mouth, throat etc. The case you have should regress in 2-3m on it's own.

RE: Severe Canine oral papillomavirus

Neil Wheadon — Mon, 03 Apr 2017 13:43:46 GMT

Any ideas what happened in this original case?

Interestingly have seen 2 in the past 6 months, here's todays

Looking for a treatment

Neil

RE: Severe Canine oral papillomavirus

Kara Gibson — Thu, 21 Jul 2016 09:04:47 GMT

We have all along been assuming these lesions would regress but at this stage, 9 months down the line, the dog has severe extensive lesions which smell foul and are the source of a lot of ongoing pain. I am surprised he is still eating but then he is a Beagle!

The RVC have suggested a course of azithromycin based on this paper http://www.ncbi.nlm.nih.gov/pubmed/18494759. They have also suggested a tumour hunt but I'm not sure if the owners will go for this.

RE: Severe Canine oral papillomavirus

Aine Seavers — Wed, 20 Jul 2016 22:54:07 GMT

Malcolm, your points are correct and your experience back in 80s would have mirrored mine. The difference is that in some new cases like these, the extent of the condition is spectacular and the distress and suffering and pain(esp in the throat swallowing etc) let alone the smell to the owner is not something to easily sit back and wait for tinc of time to heal. We used to just sedate the dog, pull and twist on the milder cases in and over 3 weeks the lesions would regress. The ones as extensive in these cases dont go away fast-and with interferon if it works then the result is spectacular within 3 days. The drug gives a return to a good quality of life fast-which has to be of merit.

RE: Severe Canine oral papillomavirus

Malcolm Ness — Wed, 20 Jul 2016 14:40:22 GMT

When I was seeing practice during the 70's, these oral papillomatosis cases were very common. Once I started in practice myself in the early 80's they were already noticeably less common and over the last twenty years I have seen, or heard of, only one or two.

I was told that the lesions regress spontaneously so patience and the passage of time was indicated. That has always been my way and I can't recall a case that hasn't resolved spontaneously. I have seen a couple of cases biopsied rather unsympathetically and another in which several of the larger lesions were removed - each of these dogs was made quite uncomfortable though they did go on and get better in the fullness of time and without specific treatment.

I am sure that the use of interferon or an autologous vaccine would be associated with a good outcome. You could even try homeopathy!!

RE: Severe Canine oral papillomavirus

Kara Gibson — Wed, 20 Jul 2016 09:43:20 GMT

Thanks everyone, I have taken samples to use for autogenous vaccine but have no experience of it and was just wondering how successful it might be.

Aines - I have emailed you some photos, thanks for your help!

RE: Severe Canine oral papillomavirus

Lindsey Edwards — Wed, 20 Jul 2016 08:43:32 GMT

As not operable to any real extent, I'd look into autovaccine if virus detected on histo if interferon not practical

RE: Severe Canine oral papillomavirus

Aine Seavers — Wed, 20 Jul 2016 08:12:32 GMT

An American Derm vet is collating these cases with the use of interferon-her results of spectacular lesions cases has been astounding-not all dogs respond but a significant amount do. Could you send me some photos to aines@bigpond.com and I will forward them on and see if she can liaise direclty with you about this case and treatment

RE: Severe Canine oral papillomavirus

David Mills — Wed, 20 Jul 2016 00:28:32 GMT

Ouch.

I'd remove as many as I could under ga with careful cautery..

RE: Severe Canine oral papillomavirus

Kara Gibson — Tue, 19 Jul 2016 19:04:38 GMT

I'm pretty wary about excision as the lesions are so extensive, they go all the way back into the throat. I've seen cases in the past with multiple lesions (although never like this) and they have always gone away on their own but these are not and they represent a serious welfare issure for him.

RE: Severe Canine oral papillomavirus

Gerry Polton — Tue, 19 Jul 2016 15:28:16 GMT

Can you send a photo? Optimal management of these seems to be excision of as much affected tissue as possible. My assumption is that the widespread inflammation (destruction) of virally transformed cells results in exposure of the remaining disease to the immune system and eventual clearance of and residual disease. I understand that some cases resolve spontaneously. I also know that these patients can be extremely depressed with the disease so it is not reasonable to simply cross one's fingers and wait for a spontaneous resolution that may never happen.

Please let us know what happens, whatever you decide. These are unusual cases so we can all learn from your (undoubted) success.

Gerry