Nexguard Spectra side effects?

RE: Nexguard Spectra side effects?

Sarah Keir — Mon, 07 Nov 2016 18:36:34 GMT

I believe Certifect has been withdrawn from the market. My husband was very ill after I used it on my dog and then he unknowingly stroked her and a nurse got migranes after using it on her dog (she doesn't usually get migranes) - it was all properly reported. It contains amitraz so not really surprising if anyone can remember bathing a demodex dog!

RE: Nexguard Spectra side effects?

Anthony Dennison — Tue, 01 Nov 2016 08:50:36 GMT

[quote user="Utlendigur"]

Slight tangent, but to the person "monitoring" this forum on behalf of merial, for your information I reported both the animal and human adverse reactions via SARRS at the time so you already have the full details and I have no wish to contact you directly. I find the idea of drugs companies monitoring social media somewhat threatening, especially given the lack of interest when reported through conventional channels...

[/quote]

It's not just Merial, NOAH monitor it too.

RE: Nexguard Spectra side effects?

Utlendigur — Mon, 31 Oct 2016 18:28:44 GMT

RE: Nexguard Spectra side effects?

Bob Russell — Mon, 31 Oct 2016 09:54:15 GMT

Just because a product is not licenced to kill all Uk species does not mean it does not work. As I understand it the reason the hedgehog tick is not included is because it is very expensive to buy and therefore test!

Did find the rep a little overly pushy regarding the 'extra' benefit of Simparica, I suspect more marketing than real!

One or two people have reported small, dead ticks but not engorged. Not seen a single one on any of our dogs so overall happy with the product. Seresto has failed (flea wise) miserably in one case but this is a dog that swims constantly and I suspect is facing a massive challenge.

RE: Nexguard Spectra side effects?

janine redman — Sun, 30 Oct 2016 19:53:49 GMT

Nexguard and bravecto both work very well against the ticks here in the New Forest. Even better than the seresto collar. And we don't have a lot of angiostronglyus , though we have crenosoma vulpis

only one bad side effect of drowsiness with vomiting and diarrhoea but owner said it affected both her dogs so unlikely I think. Bravecto does last longer than three months as was still killing ticks four months later when I forgot to give the next dose to mine.

RE: Nexguard Spectra side effects?

Glenn Hodgson — Sun, 30 Oct 2016 18:37:45 GMT

Anyone got views regarding simparica? we are thinking of moving our full healthy pets club across to it. currently using Practic

I did not think the tick kill time of nexguard was fast enough and killed enough tick species for our liking.

We are all about the ticks up here. nice and cold, you can keep your lungworm!

RE: Nexguard Spectra side effects?

Bob Russell — Sun, 30 Oct 2016 16:56:43 GMT

Hundreds of doses and no issues reported beyond the Chihuahuas getting the sh1ts. Used since without untoward effects.

RE: Nexguard Spectra side effects?

Utlendigur — Sun, 30 Oct 2016 13:19:04 GMT

But equally there may be something in it at times - anyone remember Droplix? I used to be quite sceptical aswell but had a really unpleasant experience using Certifect on my 2 fit healthy adult dogs. I was aware it could cause sedation but did not expect them to be so ill, and extremely sedated and ataxic to the point of struggling to walk. I also experienced bad drowsiness and headaches (which meant I couldn't drive to the surgery to get atipamezole for them!). Problem resolved a few hours after washing to bl**dy stuff off. Colleague also had the same problem with her dog, as did several clients. Merial were unhelpful and defensive when I reported it. I notice on their products page that it isn't listed anymore...

RE: Nexguard Spectra side effects?

Gillian Mostyn — Sun, 30 Oct 2016 12:49:16 GMT

There also seems to be a big 'bravecto kills dogs' campaign at the moment, especially on Facebook.

When we're dispensing 1000s of doses of some drugs every day, some of the pets will have an unexplained sudden death, same as in the general population.

RE: Nexguard Spectra side effects?

Stephen Courtney — Sat, 29 Oct 2016 22:14:29 GMT

I use nexgard spectra on my own dog as she doesn't seem terribly well after advocate. she's a 3.8kg chihuahua cross. On my second pack of three and very happy. I'm not too sure about the lungworm issue but the dose of milbemycin she gets in the tablet is the same as she would get on milbemax which is licensed...so go figure.

the last client I had who thought all effective parasite treatments were a Big Pharma conspiracy doesn't come to me any more after i told her she was letting her ill informed prejudices harm her flea allergic dog...I'm not sorry.

RE: Nexguard Spectra side effects?

toby travis — Sat, 29 Oct 2016 19:45:00 GMT

Hi, spotted this post from a few months ago - has anyone had any side effects from Nexgard Spectra? We are having a tricky time as very sadly an 8 year old pug died early one morning, 36 hours after a Nexgard Spectra tablet was dispensed by us for the 1st time. To cut a long story short, the dog had lots of tracheal and oesophageal mucus and significant BOAS on an independent Post Mortem at a lab but I am now aware of a Facebook page with 2900 members who want Nexgard Spectra banned and an online petition to this effect too. This has convinced the owner that the tablet is the cause and I suspect this has a long way to run for us. Merial have been very helpful so far, I was just wondering if anyone has had much in the way of side effects (especially anything respiratory) - as you can imagine, the facebook posts make it sound lethal stuff and that side effects are common yet I've not encountered any so far when prescribing it.

RE: Nexguard Spectra side effects?

Lucy Fleming — Thu, 23 Jun 2016 08:45:39 GMT

[quote user="niall morton"]

Sell allot of bravecto and no problems but have seen a facebook group with 14000 members asking 'does bravecto kill dogs?'

Usual stories....i remember when I graduated being told by a client that rimadyl kills dogs. unfortunately in a facebook culture these things get momentum quickly

[/quote]

I think most pet drugs have one of those pages nowadays. I was kicked out of 'Pet Vaccine Education' but it was fun while it lasted...

RE: Nexguard Spectra side effects?

niall morton — Wed, 22 Jun 2016 23:18:52 GMT

Sell allot of bravecto and no problems but have seen a facebook group with 14000 members asking 'does bravecto kill dogs?'

Usual stories....i remember when I graduated being told by a client that rimadyl kills dogs. unfortunately in a facebook culture these things get momentum quickly

RE: Nexguard Spectra side effects?

Martin Atkinson — Wed, 22 Jun 2016 18:16:50 GMT

[quote user="Sarah Keir"]Though why on earth they should bring it out before they got this license is a bit suspicious[/quote]I went to a market research discussion group on 17th Feb 2015 (I know it that accurately because its recorded in my CPD - you know: Plan; Do; Record; Reflect)!

Although the company and the product was supposedly a secret it was pretty thinly veiled and it was obviously Nexguard Spectra. The person hosting the group kept on pushing the question if we would use this product for angiostrongylus if it had a licence and all of us kept saying we would consider it but it doesn't. These people are supposed to be unbiased and independent but it seemed she had a (not very well) hidden agenda. The product came out very shortly afterwards. It would seem that Merial were trying a balancing act of waiting for the licence with the commercial need to get a return on their investment and chose the latter.

Our Merial rep came in soon after launch and was following much the same tack as the host at the research group like 'we know its not licensed but it still works'.

Sadly that's as good a conspiracy theory as I can give you.

RE: Nexguard Spectra side effects?

Thomas Johnson — Wed, 22 Jun 2016 18:13:27 GMT

[quote user="Sarah Keir"]

We can't say it is effective against Angiostrongulus vasorum - it doesn't have a license for this. Though why on earth they should bring it out before they got this license is a bit suspicious ;-)

[/quote]

I suspect they aren't going to get a license for it. I don't know whether this is true but I was told by an MSD rep yesterday that Merial have applied for a second time to get a license for angiostrongylus treatment for Nexgard Spectra and been refused again.

RE: Nexguard Spectra side effects?

Sarah Keir — Wed, 22 Jun 2016 17:45:55 GMT

We can't say it is effective against Angiostrongulus vasorum - it doesn't have a license for this. Though why on earth they should bring it out before they got this license is a bit suspicious ;-)

RE: Nexguard Spectra side effects?

Hannah Wynne Richards — Wed, 22 Jun 2016 17:18:54 GMT

I believed the Merial rep

Oh well - back to panacur

Wynne

RE: Nexguard Spectra side effects?

Thomas Johnson — Wed, 22 Jun 2016 17:06:31 GMT

[quote user="Hannah Wynne Richards"]

I use it. like it as it's effective against angiostrongylus. and no probs so far.

[/quote]

I would be very cautious about recommending Nexgard Spectra for lungworm, although it has milbemycin in it the license for lungworm treatment has been rejected:

A single study was performed in the EU in dogs experimentally infected with third stage larvae of Angiostrongylus vasorum to evaluate the efficacy of two dosage regimens. In this study, the standard efficacy threshold of 90% was not achieved. Therefore, these data are considered inadequate to support the following proposed indication: “In endemic areas administration of the product every four weeks will prevent angiostrongylosis due to Angiostrongylus vasorum by reducing immature adult (L5) and adult parasite burden.” The proposed indication for use against Angiostrongylus vasorum was therefore withdrawn during the procedure.

Full document:

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/veterinary/003842/WC500181963.pdf

RE: Nexguard Spectra side effects?

chris Jones — Wed, 22 Jun 2016 17:03:32 GMT

just checked and its a different 'laner than the bravecto but i doubt that would change much.

RE: Nexguard Spectra side effects?

Bob Russell — Wed, 22 Jun 2016 16:59:19 GMT

One of the reps from another company told us with great glee, that it had failed to get a licence for lungworm. Not seen the Merial rep recently but still seems to be a good all-rounder.

RE: Nexguard Spectra side effects?

Hannah Wynne Richards — Wed, 22 Jun 2016 16:40:42 GMT

I use it. like it as it's effective against angiostrongylus. and no probs so far.

Wynne

RE: Nexguard Spectra side effects?

Bob Russell — Wed, 22 Jun 2016 16:36:37 GMT

Chihuahuas were within the recommended weight band. This particular client is a keen user of the internet so I have major doubts about the severity or otherwise of symptoms.

The bad reviews are one daily or every other day. Not the usual cluster I would expect with genuine side effects. All the reviewers are new and have reviewed only once!

I seem to remember a member of staff working for a competitor American company was found posting adverse reactions before a particular product had actually reached practices!

RE: Nexguard Spectra side effects?

Martin Atkinson — Wed, 22 Jun 2016 16:30:26 GMT

How heavy are the Chihuahuas? Nexguard is not indicated for dogs <2kg I wonder how close to the limit they were. Also I wonder if Afoxolaner is similar in its mode of action as Amitraz which is well know to be an issue in the breed.

RE: Nexguard Spectra side effects?

chris Jones — Wed, 22 Jun 2016 16:20:39 GMT

Hi Bob,

can't comment directly about nexguard spectra but we sell a huge amount of bravecto and I think its the same active ingredient (minus the wormer side) but a much higher dose and we have had absolutely no problems so far (used it since its launch). I would have expected side effects as the dose is high end to get it to last 3 months so a lower monthly dose should be safer.

I have used the standard nexguard on my own dog as I wimped out of the bravecto dose and she is fine. Sounds like typical internet - all drugs are bad - information, so best use witchcraft homeopathy instead!

We regularly get side effects (albeit mild) with Vectra, broadline, comfortis etc but cant recall any with bravecto. From what I am aware (I think!) the only difference is the combination of the wormer side and lower fluralaner dose.

chris