https://www.vetsurgeon.org/f/clinical-questions/24453/azithromycin-in-rabbits-orally Hi everyone :) I have a rabbit that is not 100% resolved on baytril, tmps or injectable penicillin EOD that I&#39;ve inherited with a chronic URT infection. I was considering doing a swab for C/S, Otherwise has anyone used azithromycin in rabbits orallyen-USTelligent Community 10https://www.vetsurgeon.org/thread/160518?ContentTypeID=1Wed, 22 Jun 2016 10:16:26 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:c3a32d6c-dfd9-4639-ae81-b1552918caf3Marie Kubiak<p>I use 10mg/kg bid. Rarely do we see side effects but if seem they seem to be GI pain related (hunched, anorexic) and resolve quickly with syringe feeding and analgesia.</p> <p>Definitely worth working this case up and at this stage owners can often be persuaded to do at least culture as C&amp;S is cheaper than multiple further courses of antibiotics. Unfortunately by the time symptoms are chronic there are often pockets of infection in sinuses which cannot be cleared medically and permanent clearance is rare. Surgical debridement is then needed to attempt resolution or palliative pulse courses of antibiotics to manage flare ups. Other considerations are nasal FBs, concurrent LRT or bulla infection, dental associated sinusitis, osteomyelitis and maxillary dental abscessation so I recommend rhinoscopy and rads too. If declined then go with azithromycin or a combination of entofloxacin and metronidazole but we very commonly see penicillin resistance in rabbit cultures so rarely use this any more. Also worth adding in meloxicam, it may reduce nasal passage swelling slightly or may make the rabbit feel more comfortable.</p> <p>Marie</p><div style="clear:both;"></div>