Polyuria/polydipsia in elderly dog

RE: Polyuria/polydipsia in elderly dog

Stigen — Fri, 13 May 2016 09:18:05 GMT

Thank you guys ! Nice to have such clear consensus on the next step !
I did think this dog was cushingoid from the onset, but just did`nt get a clear answer from the acth stim. So I will do a low dose dex, and I guess there`s not much point in doing a urine cratinine/cortisol ratio when I`ve done both of the other tests.

RE: Polyuria/polydipsia in elderly dog

Sarah Keir — Fri, 13 May 2016 09:11:37 GMT

An ACTH stim has a relatively high specificity for hyperadrenocorticism but much lower sensitivity (mid 80% or so). The LDDST has higher sensitivity but lower specificity. I vote for doing a LDDST too.

RE: Polyuria/polydipsia in elderly dog

Noweia — Thu, 12 May 2016 22:49:50 GMT

Eating well or eating excessively? Another vote for LDDST here.

RE: Polyuria/polydipsia in elderly dog

MattB — Thu, 12 May 2016 14:43:49 GMT

I agree - Cushings - it may be Atypical Cushings. LDDST as a next step (but may not respond if it is Atypical Cushings). Watch out for sudden acquired retinal degeneration too.

Matt

RE: Polyuria/polydipsia in elderly dog

Kate Richardson — Thu, 12 May 2016 13:54:51 GMT

Another vote for Cushings until proved otherwise, so I'd be doing a low dose dex suppression test next as well. Have you done a urine culture? I commonly find Cushings dogs have a concurrent UTI which exacerbates the PUPD

RE: Polyuria/polydipsia in elderly dog

David Mills — Thu, 12 May 2016 12:30:52 GMT

Looks cushingoid.

I have little faith in acth stim.

Low dose dex test would be next in my book with that alp.

Pupd due to primary liver normally a lot more deranged e.g. bike acids normally out.