Attention all vets - furosemide in dogs

RE: Attention all vets - furosemide in dogs

emma o'connor — Wed, 17 Feb 2016 13:15:46 GMT

[quote user="Martin Atkinson"]Who else put polydypsia as another 'side effect' which it is if polyuria is the desired mode of action?[/quote]

I did!

RE: Attention all vets - furosemide in dogs

Robin Grimmer — Wed, 17 Feb 2016 12:23:44 GMT

I agree with Clive. Calling polyuria a side effect of a diuretic is a bit like calling diarrhoea a side effect of a laxative.

RE: Attention all vets - furosemide in dogs

Anthony Todd — Wed, 17 Feb 2016 12:01:17 GMT

[quote user="Clive Ansell"]Polyuria is not really an adverse effect either[/quote]

Well it is if it's on the persian carpet...

Be better if the H and the O could be attached to flatulence, for instance, or passed in expired air?

RE: Attention all vets - furosemide in dogs

Clive Ansell — Wed, 17 Feb 2016 10:38:30 GMT

[quote user="Niall Taylor"]

A better term might be adverse effect. A drug effect would be either a desired effect or an unwanted effect, and if it's unwanted, it's adverse.

Diuretics' principal effect is to make animals pee more, but that doesn't make it a desired effect.

Side effect is too vague.

[/quote]

Polyuria is not really an adverse effect either, it is what we would expect a diuretic to do. Maybe just "an effect, or normal effect" Could well be undesirable to the client, but it is doing exactly what we want it to do, in getting rid of excess fluid.

RE: Attention all vets - furosemide in dogs

Martin Atkinson — Wed, 17 Feb 2016 10:37:42 GMT

As Nicole's survey was primarily aimed at the client's perspective I'm sure most of them would view polyuria as an undesirable side effect. Who else put polydypsia as another 'side effect' which it is if polyuria is the desired mode of action?

RE: Attention all vets - furosemide in dogs

Niall Taylor — Wed, 17 Feb 2016 10:20:17 GMT

[quote user="Clive Ansell"]Technically not a side effect, as polyuria is the primary action of the drug through reduced solute re absorption in the nephron, subsequent water loss and a hypotonic urine.[/quote]

A better term might be adverse effect. A drug effect would be either a desired effect or an unwanted effect, and if it's unwanted, it's adverse.

Diuretics' principal effect is to make animals pee more, but that doesn't make it a desired effect.

Side effect is too vague.

Niall (in full pedant mode)

RE: Attention all vets - furosemide in dogs

Clive Ansell — Tue, 16 Feb 2016 22:47:09 GMT

Technically not a side effect, as polyuria is the primary action of the drug through reduced solute re absorption in the nephron, subsequent water loss and a hypotonic urine.

RE: Attention all vets - furosemide in dogs

Glen McIntosh — Tue, 16 Feb 2016 22:23:24 GMT

[quote user="Sammy82"]I have just taken the survey. One thing I would like to point out is that polyuria is not a side effect, it is the desired effect of a diuretic like frusemide. [/quote]

Not sure I agree with this.

The desired effect of frusemide when used to treat CHF is to reduce pulmonary oedema.

Polyuria certainly is a side effect of this drug, but most certainly NOT a desired effect (even if is to be expected as a result of the drug's mechanism of action that is used to achieve the desired effect). Just ask any owner.

RE: Attention all vets - furosemide in dogs

Sammy82 — Tue, 16 Feb 2016 16:47:36 GMT

I have just taken the survey. One thing I would like to point out is that polyuria is not a side effect, it is the desired effect of a diuretic like frusemide.