Oral Squamous Cell Carcinoma

RE: Oral Squamous Cell Carcinoma

Anthony Todd — Sat, 24 Oct 2015 13:55:54 GMT

[quote user="Evelyn Barbour-Hill"]Yes of course, but then you are always right about everything anyway. [/quote]

Remember he is single handed, so no peer review, ever. [you started it Martin....]

RE: Oral Squamous Cell Carcinoma

Stephen Courtney — Sat, 24 Oct 2015 11:09:26 GMT

Sorry to hear that but ultimately the choice is inevitable. I have also seen some good results in palliative care with meloxicam, and also piroxicam (Feldene) though this is much more difficult to use safely in cats. Palladia does have the potential to work well in soem individuals and might be worth a try before giving up, if it works results are fairly quick to appreciate.

Incidentally, regarding your dentistry I assume you mean open rather than closed extractions? All extractions are acts of surgery....!

I really hate dealing with old cats with overdue dentals that then turn out to have SCC....such a pity that early SCC blends into periodontal disease so well.

RE: Oral Squamous Cell Carcinoma

Thomas Johnson — Sat, 24 Oct 2015 09:45:10 GMT

[quote user="J G Wray"]

From the San Diego conference a couple of weeks ago

Oral Tumors in Cats: Hope for the Future, Dr. Annette Smith

Feline oral squamous cell carcinoma remains a challenging disease to treat, with a generally poor prognosis. Surgery can be useful for selected cases, usually with mandibular and rostral, small tumors, with long-term survivals.
Palladia has shown some treatment responses in cats with oral squamous cell carcinoma, and appears to be well-tolerated. With the identification of further potential targets, in conjunction with the development of targeted therapy, better treatment options for this disease may be on the horizon.

[/quote]

I discussed the results with the owners last night, and they have booked the cat in for euthanasia today as it is showing signs of discomfort despite pain relief, and is lethargic and eating very little.

RE: Oral Squamous Cell Carcinoma

J G Wray — Sat, 24 Oct 2015 09:25:31 GMT

From the San Diego conference a couple of weeks ago

Oral Tumors in Cats: Hope for the Future, Dr. Annette Smith

Feline oral squamous cell carcinoma remains a challenging disease to treat, with a generally poor prognosis. Surgery can be useful for selected cases, usually with mandibular and rostral, small tumors, with long-term survivals.
Palladia has shown some treatment responses in cats with oral squamous cell carcinoma, and appears to be well-tolerated. With the identification of further potential targets, in conjunction with the development of targeted therapy, better treatment options for this disease may be on the horizon.

RE: Oral Squamous Cell Carcinoma

Thomas Johnson — Sat, 24 Oct 2015 09:12:39 GMT

[quote user="Evelyn Barbour-Hill"]

1. I don't believe you can often tell SCC fom severe chronic inflammation by looking.

2. SCC will be missed on a biopsy unless the biopsy is deep enough. At the back of a cat's mouth it's quite easy to miss the neoplastic tissue, unless like Macbeth you are bloody, bold and resolute.

3. I think the SCC was there all along. Of course he had FCGS as well.

4. On the other hand, it does seem, in general, that some cancers can be induced by severe chronic inflammation.

[/quote]

Two and a half years felt like too long for the SCC to have been there all along, but I suppose it is possible, especially as the rest of the FCGS settled completely once I had extracted the teeth.

[quote user="Robin Grimmer"]

I don't know of any specific link, but SCC is the commonest oral neoplasm in cats. How did you perform the extractions, out of interest?

[/quote]

The extractions were performed non-surgically, and on the radiographs I took this week I can't see any root fragments.

RE: Oral Squamous Cell Carcinoma

Evelyn Barbour-Hill — Fri, 23 Oct 2015 19:25:22 GMT

[quote user="Martin Atkinson"][quote user="Evelyn Barbour-Hill"] I don't believe you can often tell SCC fom severe chronic inflammation by looking.[/quote]You're right, its not diagnostic, but to my eyes there is a distinct difference and if histology results are to be believed I don't recall my hunch being wrong yet.[/quote]

Yes of course, but then you are always right about everything anyway.

RE: Oral Squamous Cell Carcinoma

Martin Atkinson — Fri, 23 Oct 2015 19:19:09 GMT

[quote user="Evelyn Barbour-Hill"] I don't believe you can often tell SCC fom severe chronic inflammation by looking.[/quote]You're right, its not diagnostic, but to my eyes there is a distinct difference and if histology results are to be believed I don't recall my hunch being wrong yet.

RE: Oral Squamous Cell Carcinoma

Evelyn Barbour-Hill — Fri, 23 Oct 2015 19:14:18 GMT

1. I don't believe you can often tell SCC fom severe chronic inflammation by looking.

2. SCC will be missed on a biopsy unless the biopsy is deep enough. At the back of a cat's mouth it's quite easy to miss the neoplastic tissue, unless like Macbeth you are bloody, bold and resolute.

3. I think the SCC was there all along. Of course he had FCGS as well.

4. On the other hand, it does seem, in general, that some cancers can be induced by severe chronic inflammation.

RE: Oral Squamous Cell Carcinoma

Martin Atkinson — Fri, 23 Oct 2015 19:03:10 GMT

[quote user="Thomas Johnson"]Does anyone know if there is a link between feline gingivostomatitis and oral squamous cell carcinoma?[/quote]There may be a chicken and egg going on here and what you see is a common scenario. I often see severely neglected FGS lesion in cats which when biopsied turn out to be SCC's. Question is which came first? There is little doubt that chronic inflammation can lead to neoplastic change so in answer to your question I'd say there is but it does depend on how representative the original biopsies were or how well they were interpreted. IME the appearance of even severe FGS is distinct from SCC so my hunch in this case is that your colleague was right and this has subsequently progressed. The frequency of this apparent transition seems a little to great for it to be coincidental.

RE: Oral Squamous Cell Carcinoma

Robin Grimmer — Fri, 23 Oct 2015 17:59:20 GMT

I don't know of any specific link, but SCC is the commonest oral neoplasm in cats. How did you perform the extractions, out of interest?