Urine retention in a dog

RE: Urine retention in a dog

Anthony Todd — Tue, 25 Aug 2015 21:17:37 GMT

Thanks Andrew, hope someone tries it.

RE: Urine retention in a dog

Andrew Kent — Tue, 25 Aug 2015 19:51:16 GMT

[quote user="Anthony Todd"]

[quote user="Andrew Kent"]tamsulosin[/quote]

Having had amazing personal results with tamsulosin, as opposed to blood-curdling "mechanical" methods in Australia, it occurred to me that it might be useful in blocked cats. I don't think it is licensed for use in animals though?

Anyone have any info or experience, in animals that is.....

[/quote]

Hi Anthony,

There is little known in cats and dogs about which urethral relaxant is best and, essentially, nothing licensed so all use is under the cascade. In the UK tamsulosin doesn't seem to be that widely used, whereas when I was working in the US it is used much more often.

The little evidence that exists suggests that tamsulosin may be more effective than prazosin (in dog ureters at least).

The potency of KUL-7211, a selective ureteral relaxant, in isolated canine ureter: comparison with various spasmolytics.

Wanajo I1, Tomiyama Y, Tadachi M, Kobayashi M, Yamazaki Y, Kojima M, Shibata N.

Author information

Abstract

We compared the potency of a selective ureteral relaxant KUL-7211 (beta(2)/beta(3)-adrenoceptor agonist; (-)-2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenyloxy]acetic acid) with those of various spasmolytics on contractions in isolated canine ureteral preparations. Drug effects were evaluated on the tonic contraction induced by KCl (80 mM) and on spontaneous, 1x10(-5) M phenylephrine-, and 1x10(-6) M PGF(2alpha)-induced rhythmic contractions in isolated canine ureteral preparations using a functional experimental technique. The potencies (pD(2) value) of the following drugs were compared: KUL-7211, tamsulosin (an alpha(1A/1D)-adrenoceptor antagonist), prazosin (an alpha(1)-adrenoceptor antagonist), verapamil (a Ca(2+)-channel blocker), butylscopolamine (a nonselective muscarinic antagonist), and papaverine (a phosphodiesterase inhibitor). The rank order of relaxing potencies against KCl-induced tonic contraction was KUL-7211 (6.60)>tamsulosin(5.90)>verapamil(5.70)>papaverine(4.88)>prazosin (4.54). The rank order of potencies for reductions in spontaneous rhythmic contractions was KUL-7211 (6.80)>verapamil(6.12)>papaverine(5.05). Conversely, high concentrations of the two alpha-adrenoceptor antagonists (tamsulosin and prazosin) and of butylscopolamine enhanced the spontaneous contractions, although at low concentrations (up to 1x10(-6) M) they had no significant effects. For suppression of spasmogen-induced rhythmic contractions, the rank order of potencies was, against phenylephrine-induced contractions: KUL-7211 (6.95)>tamsulosin(6.26)>prazosin(5.68)>verapamil(5.64)>papaverine (5.03), and against PGF(2alpha)-induced contractions: KUL-7211 (7.05)>verapamil(6.70)>papaverine (5.27). Our results suggest that in dogs, the beta(2)/beta(3)-adrenoceptor agonist KUL-7211 is the most efficacious ureteral relaxant among the spasmolytics tested against various contractions. Possibly, KUL-7211 might be useful for promoting stone passage and relieving ureteral colic in urolithiasis patients.

Andy

RE: Urine retention in a dog

Anthony Todd — Tue, 25 Aug 2015 14:14:12 GMT

[quote user="Andrew Kent"]tamsulosin[/quote]

Anyone have any info or experience, in animals that is.....

RE: Urine retention in a dog

Anthony Todd — Thu, 20 Aug 2015 17:08:17 GMT

4cms sounds like a big prostate to me??? [not personally, to be clear]

Can you press on it and get some prostatic fluid??

RE: Urine retention in a dog

Andrew Kent — Thu, 20 Aug 2015 10:02:23 GMT

[quote user="Ian Ross"]

have you got any further with this case?

We have one a little similar, 4 year old R. Ridgeback. Neutered male. Overflow incont, Urine sample unremarkable, double contrast cystogram unremarkable. No signs stones.

Urinary catheter passes very easily each time. Just standing and dribbling urine. Bladder full on palpation, but can express with manual pressure on the abdomen at times. Doesn't seem to have urethral sphinctor blockage.

Started on myotonine after xrays on Monday. No response yet.

[/quote]

Hi Ian,

It may be worth using a urethral relaxant (prazosin/tamsulosin/phenoxybenzamine) in addition to the myotonine, unless the bladder is very very easy to express, otherwise increasing detrussor tone can be uncomfortable.

Did your imaging include a urethrogram? Or just a cystogram? If not it may be worth doing so to exclude urethral disease.

Andy

RE: Urine retention in a dog

nikki — Wed, 19 Aug 2015 22:11:29 GMT

Spoke to a medicine specalist who recommended putting him on phenoxybenzamine while we wait for the owner to come back from holiday to go to the referral appointment. He has started that today so will be interested to see if it helps.

RE: Urine retention in a dog

Ian Ross — Wed, 19 Aug 2015 17:15:48 GMT

have you got any further with this case?

We have one a little similar, 4 year old R. Ridgeback. Neutered male. Overflow incont, Urine sample unremarkable, double contrast cystogram unremarkable. No signs stones.

Started on myotonine after xrays on Monday. No response yet.

RE: Urine retention in a dog

Joyce Whitehead — Sat, 15 Aug 2015 18:45:51 GMT

We also had one in a Labrador that turned out to be discospondylitis, and once diagnosed, resoonded really well to antbiotics.

RE: Urine retention in a dog

Stephen Courtney — Sat, 15 Aug 2015 14:11:55 GMT

The last dog i dealt with that had urine retention was a 5 year old Dogue de Bordeaux. He turned out to have cauda equina syndrome and a generally spondylosed and nasty lumbosacral spine. It did not end well, and there was fairly protracted diagnostic trail involving several months and two different specialists.

RE: Urine retention in a dog

Andrew Kent — Fri, 14 Aug 2015 14:32:04 GMT

Hi Nikki,

I would echo the thoughts about neurological causes here - can you express the bladder manually? With normal/increased/decreased tone? Are there any other neurological deficits? Normal hopping/proprioception? Normal anal and tail tone?

Assuming all that looks normal I would do a retrograde urethrogram to assess the urethra more clearly.

Andy

RE: Urine retention in a dog

Kara Gibson — Fri, 14 Aug 2015 02:59:40 GMT

Possible neurological issue? When you apply pressure to his bladder will he get a good stream going?