Doxorubicin administration

Re: Doxorubicin administration

Anthony Dennison — Tue, 05 May 2015 13:22:11 GMT

A dog I sent to an oncologist for chemo after the removal of a high grade sarcoma didn't use doxorubicin because the dog had a heart murmur.

Re: Doxorubicin administration

Martin Atkinson — Tue, 05 May 2015 09:24:17 GMT

As long as it takes a 100ml saline drip to run though at one drop a second so about 15-20 minutes. I still have someone on suicide watch though.

Nontheless, I had one CKCS with lymphoma drop of the needle presumably from cardiac arrest due to pre-existing cardiac disease. Its brother which by sad coincidence was diagnosed at the same time was OK but the owner decided to abort the course as a precaution. It did make me wonder if we should scan all animals for cardiac disease, especially those breeds at risk, before giving dox. This dog was asymptomatic and had no murmur.

Re: Doxorubicin administration

Braden Collins — Mon, 04 May 2015 23:47:18 GMT

Doxorubicin is very toxic to tissues. If given over 6 hours you either need someone sitting with it for the whole time or you risk it going extra vascular and causing a massive slough.

Re: Doxorubicin administration

becka_scotland — Mon, 04 May 2015 17:08:02 GMT

Thanks :)

Do you know why this particular time was chosen as I know some studies tried it over 10minutes and found fairly high toxicity and other studies found less toxicity over 6hours plus?? I.e why don't we therefore give it over 6hours?!

Re: Doxorubicin administration

Braden Collins — Mon, 04 May 2015 12:24:42 GMT

15-20 minutes