Desmopressin tablets v nasal drops

Re: Desmopressin tablets v nasal drops

Stephen Courtney — Wed, 18 Feb 2015 22:13:04 GMT

I have a boxer dog, 7 year old Mn with huge PU/PD - urine Sg is 1.003 - normal bloods, and that's as far as the owner has let me go diagnostically.

Very frustrating - wrote a script for DDAVP drops, and no feedback in spite of promises.....

I have him on 0.1ml of the nasal drops bid into the eyes. but no idea how it's going. i don't often get cases like this, and have never had one that I was able to investigate properly, but have had two that responded very well to the DDAVP drops.

Personally i think this dog has a boxernoma pressing on his thirst centre and nothing else...yet. I would love to refer him for a proper work up and all the imaging, but funds preclude.

Re: Desmopressin tablets v nasal drops

Kate Richardson — Wed, 18 Feb 2015 20:13:00 GMT

Maybe not but no other cause found so far.

Re: Desmopressin tablets v nasal drops

Martin Atkinson — Wed, 18 Feb 2015 18:57:03 GMT

[quote user="Kate Richardson"]Great thanks, Have a case I have ruled out all other causes and am trialling desmopressin but so far minimal response and approaching max dose. Will suggest trying the drops if no improvement after latest dose increase.[/quote]Probably more likely its just not DI!

Re: Desmopressin tablets v nasal drops

Kate Richardson — Wed, 18 Feb 2015 18:54:01 GMT

Great thanks, Have a case I have ruled out all other causes and am trialling desmopressin but so far minimal response and approaching max dose. Will suggest trying the drops if no improvement after latest dose increase.

Re: Desmopressin tablets v nasal drops

Alex Gough — Wed, 18 Feb 2015 16:11:07 GMT

We were just chatting about this yesterday, and our feeling is that the tablets arent as effective as the drops. I believe they have poorer bioavailability, and we have had cases that respond to drops but not tablets.

Re: Desmopressin tablets v nasal drops

Virginia Campbell — Wed, 18 Feb 2015 15:26:33 GMT

Hi all,

Have suspected central DI in the practice and am going to try desmopressin response. I have the nasal drops 100ug/ml made by Ferring pharmaceuticals, and am wondering how to administer. Subconjunctival like my textbooks say or just like a kennel cough vax?

I'm also tempted to do a subcutaneous injection with insulin syringe for the first trial dose to rule out administration failure (sneezing or blinking it out). OK is not ideal as technically not sterile, but the bottle isn't broached yet and I reckon would be v unlucky to get a hideous abscess from one <0.05ml injection. Does anyone else do this for the first dose?

I realise that, due to medullary washout, it might take a week's worth of treatment to get a good response (am feeding the dog puppy food with a little sprinkle of salt on) and will need to get owner doing intranasal or subconjunctival drops.

Thanks all

Ginny

Re: Desmopressin tablets v nasal drops

Martin Atkinson — Thu, 12 Feb 2015 09:09:25 GMT

Given that diabetes insipidus is often a spurious diagnosis, response to any form is debatable. But the odd cases I have managed I used tablets. Less expensive and more certainty the full dose has been absorbed assuming the patient is pillable.

Re: Desmopressin tablets v nasal drops

Glenn Hodgson — Wed, 11 Feb 2015 19:55:46 GMT

I like tabs now. Drops are getting more costly.

Re: Desmopressin tablets v nasal drops

Charlotte Marshall — Wed, 11 Feb 2015 19:51:16 GMT

I didn't realise you could get tablets. If they work as well it would be a lot easier.