https://www.vetsurgeon.org/f/clinical-questions/21109/pu-pd-rabbit-with-hypercalcaemia Hello all, This is a 2y 10 mth old female rabbit, presenting for dacryocystitis, but is also pupd, drinking over one full large water bottle daily. She is eating hay with small amount of pellets and is otherwise normal (read &#39;feisty&#39;). She has losten-USTelligent Community 10https://www.vetsurgeon.org/thread/127710?ContentTypeID=1Thu, 08 Jan 2015 16:49:32 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:48c8a711-14f5-47fa-85ab-bd8425f5eab1Marie Kubiak<p>Any idea how much is being drunk in ml/kg? Water intake normally is around 100ml/kg/d so depending on weight a full bottle (?250 or 500ml) may be acceptable. Any change in vegetables fed? Simply increasing the hay intake may cause a noticeable increase in water intake.</p> <p>The hypercalcaemia may simply be dietary and it isn&#39;t exceptional to have a serum Ca level of around 4mmol/l in perfectly healthy rabbits. However elevated calcium is often the first indication of early renal insufficiency. Not very helpful that the lab just reported &gt;4 rather than a figure though as it doesn&#39;t give you much to go on as to the level of elevation! ALP elevation may suggest increased osteoclast activity with an underlying renal secondary hyperparathyroidism but given phos and creatinine levels are fine then I wouldn&#39;t be getting too panicked. It would be wise to do urinalysis to assess SG and proteinuria - if more than a trace of protein is present then I would opt for urine microscopy and UPCR to get a bit more information on renal function. If urinalysis suggests renal dysfunction then also consider checking IgG and IgM levels against E. cuniculi as this is a common cause of chronic renal insufficiency in rabbits.</p> <p>Marie.</p><div style="clear:both;"></div>