Aludex alternative

Re: Aludex alternative

Lindsey Edwards — Sat, 03 Jan 2015 20:23:04 GMT

Bravecto has some positive anecdotal reports, off license for demodex indication but longer term action seems to help.

Re: Aludex alternative

Braden Collins — Sat, 03 Jan 2015 02:42:10 GMT

Ivomec is about all we use in our clinic (no cascade in Western Australia), and as it is mostly a juvenile problem we use it on young dogs all the time. I don't think the age is at all relevant except with a Great Dane you need to keep adjusting doses as the dog grows. As others have suggested start low and increase the dose every 5 days or so. I normally target 400-600ug/kg SID. I would certainly expect positive scrapes on ivomec/milbemax for several months after starting treatment. I will continue treatment until I have two negative scrapes 1 month apart.

Re: Aludex alternative

Neil Wheadon — Fri, 02 Jan 2015 23:26:41 GMT

According to http://www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8032

Breeds affected by the MRD1 defect are

Australian Shepherd , Border collie , Collie , English shepherd , German Shepherd , Longhaired Whippet , McNab Shepherd (McNab Border Collie) , Old English Sheepdog (Bobtail) , Shetland Sheepdog (Sheltie) , Silken Windhound , Rough Collie , Smooth Collie , Bobtail , American White Shepherd , Waeller (Wäller) , Elo

and the test cost is £72.50

Neil

Re: Aludex alternative

John Flynn — Fri, 02 Jan 2015 22:55:14 GMT

[quote user="Thomas Johnson"]You could send some blood to get it gene tested for the MRD1 defect.[/quote]

To my knowledge, the allele you can test for (i.e. the common one to cause problems) has never been reported in a Great Dane and I think it would be safe to assume that in a pedigree Great Dane this specific genetic abnormality is highly unlikely to be present, as such I wouldn't consider gene testing.

[quote user="Thomas Johnson"]Not sure why its age would be a problem with ivermectin?[/quote]

I agree here. If it is severe then I would not personally hesistate to start on oral ivermectin at a dose of 0.1mg/kg q24hrs and titrate up over a week to 0.5mg/kg q24hrs assuming no clinical signs of toxicity present. [NB: please check doses elsewhere as these are off the top of my head and could be wrong]

Re: Aludex alternative

Thomas Johnson — Fri, 02 Jan 2015 18:44:10 GMT

[quote user="Deborah Anwyl"]

Advocate was tried before the Aludex and didn't touch it but I'm not that keen on giving large volumes of ivermec to a puppy that age. Does anyone have any alternative suggestions?

[/quote]

Not sure why its age would be a problem with ivermectin? You could send some blood to get it gene tested for the MRD1 defect.

Re: Aludex alternative

Martin Atkinson — Fri, 02 Jan 2015 17:53:42 GMT

[quote user="SER"]

There are some other threads covering this but I am currently treating a canine case with milbemycin oxime (milbemax). it's off licence and the praziquantel isn't needed. I think there is a milbemycin only product but you need to import it

it's off licence and quite expensive.

I started at 0.5mg/kg sid and then increased to 1-2mg/kg.

after four weeks the dog is clinically better but still positive in scrapes.

[/quote]Wot SER said. Except the recommended dose of milbemycin is 2mg/kg sid. The stand-alone product is called Interceptor and is made by Novartis so contact them.

Re: Aludex alternative

Sara Ramsey — Fri, 02 Jan 2015 16:57:29 GMT

it's off licence and quite expensive.

I started at 0.5mg/kg sid and then increased to 1-2mg/kg.

after four weeks the dog is clinically better but still positive in scrapes.