prednisolone or methylpred does it matter?

Re: prednisolone or methylpred does it matter?

Thomas Johnson — Tue, 16 Dec 2014 17:50:46 GMT

[quote user="Anthony Todd"]

I didn't see a reply re the chemical difference between "Medrone" tabs and "Depomedrone" injection.

Are they the same, except Depomed is an injection. NOAH says one is acetate, one is "plain" and solu-medrone is the ester???

[/quote]

I can't find data on half lives for dogs, but in humans the half life for methylprednisolone is around 24 hours and for methylprednisolone acetate is around 70 hours.

Re: prednisolone or methylpred does it matter?

Anthony Todd — Tue, 16 Dec 2014 16:44:59 GMT

[quote user="Robin Grimmer"]So I think your answer is no to medrone, has to be preds only for chemo.[/quote]

Loads of articles citing use of methyl pred in humans but mainly for appetite and pain relief and not too many recent ones.

[PDF]HIGH DOSE METHYLPREDNISOLONE

www.royalsurrey.nhs.uk/Default.aspx?DN=a3c6bc3f-79e6-4071-a1ce...

Prepared by Oncology Pharmacist: S Taylor. Checked by: C Tucker. Page 1 of 2. HIGH DOSE METHYLPREDNISOLONE. A treatment option for patients with ...

Re: prednisolone or methylpred does it matter?

Alex Gough — Tue, 16 Dec 2014 15:59:23 GMT

Any of you using methylprednisolone as an immunosuppressant and if so at what dose?

Alex

Re: prednisolone or methylpred does it matter?

Robin Grimmer — Tue, 16 Dec 2014 15:51:55 GMT

From the latest BSAVA Oncology: prednisone and prednisolone bind to receptors in the nucleus and inhibits DNA synthesis. General anti tumour dose is 1-2mg per kg. Indicated for lymphoma, mcts, leukaemias and plasma cell tumours. So I think your answer is no to medrone, has to be preds only for chemo.

Re: prednisolone or methylpred does it matter?

Robin Grimmer — Tue, 16 Dec 2014 14:31:34 GMT

I've never heard of anything other than pred being used in lymphoma protocols. I don't know exactly why though.

Re: prednisolone or methylpred does it matter?

Anthony Todd — Tue, 16 Dec 2014 14:29:51 GMT

[quote user="Andrew Mellor"]Following on from another thread that has just gone off piste [/quote]

I didn't see a reply re the chemical difference between "Medrone" tabs and "Depomedrone" injection.

Are they the same, except Depomed is an injection. NOAH says one is acetate, one is "plain" and solu-medrone is the ester???

My experience with Depomed is that PU/PD wasn't a common complaint.