https://www.vetsurgeon.org/f/clinical-questions/20652/rescue-protocol-for-lymphoma I&#39;m doing locum this week and have a dog in for chemotherapy for multicentric lymphoma. He is a 9yo Sbt, histology was done on a lymph node and it came back as high grade lymphoma. Immuno phenotyping wasn&#39;t performed to see whether T or B cell. He&#39;sen-USTelligent Community 10https://www.vetsurgeon.org/thread/124465?ContentTypeID=1Fri, 14 Nov 2014 13:29:34 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:41380d09-90d9-4be8-9af4-9e4c3828a511Robin Grimmer<p>Thanks Gerry. Excellent advice as always.</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/124451?ContentTypeID=1Fri, 14 Nov 2014 12:51:49 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:38b11e4d-a945-4ef8-97da-8f99541e8026Gerry Polton<p>Hi Robin</p> <p>Sounds pretty bad. This is behaving like an Acute Lymphoblastic B/T Cell Lymphoma. If that is the case, immunophenotype would not have made any difference. If further treatment is to be pursued, doxorubicin as a sole agent offers your best chance of achieving a further remission. However, if (big assumption here) this is the kind of lymphoma I suspect it is, median life expectancy from diagnosis with a doxorubicin-based treatment plan would still only be 5 months or so. In view of the revised prognosis, the owners may choose not to proceed with further therapy. In that case, prednisolone remains a decent option; 1mg/kg once daily would be appropriate. I suspect that chlorambucil would be a complete waste of time. If the owners do wish to proceed with doxorubicin but you know there is going to be a delay in obtaining drug/referring the patient, I think a further dose of vincristine would be a very good idea. I assume he was previously receiving 0.5mg/sqm. I would happily administer 0.7mg/sqm as a matter of routine so that should be fine in this case if there have been no toxicity issues with the treatment to date.</p> <p>Best of luck</p> <p>Gerry</p><div style="clear:both;"></div>