Re: Feline CKD: proteinuria/blood pressure

Francisco Gomez — Wed, 24 Sep 2014 17:12:19 GMT

[quote user="Matt Hilary"]

is assessment of proteinuria from a sample taken at home an acceptable alternative?

[/quote]

I agree with Martin, possibly the type of test to measure is more important than the collection method. sticks do often give you false positives, UPC ratios is the gold standard.

[quote]

Or can high blood pressure cause clinical issues in the absence of proteinuria?

[/quote]

I guess so, yes. I supose you can have organ target damage (for example, retinal detachment) even without signs of renal disease: Idiopathic hypertension.

[quote]

Many thanks.

[/quote]

It's a pleasure!

Re: Feline CKD: proteinuria/blood pressure

Martin Atkinson — Wed, 24 Sep 2014 13:28:20 GMT

If you can measure BP at all it will give some guidance the 'white coat effect' IME is only worth about 10-20 so if its BP is >175 then this is still significant.

A few more figures on the stage of renal failure would be useful and other things like potassium as well. I see no reason at all why a free catch sample at home would be problem for urine analysis but raised urine protein alone is not enough unless the urine is very hyposthenic. A urine protein:creatinine ratio gives much more information. A number of cats with CKD will produce isothenuric urine and have protein levels commensurate with that.

Hypertension and proteinuria are just part of the vicious cycle of renal failure one making the other worse but hypertension will of course cause other clinical issues regardless notably detached retinas. If you've not already done it, It is worth doing a T4 at the same as the renal tests just in case this is entering into the equation.