https://www.vetsurgeon.org/f/clinical-questions/19041/rat-lymphadenopathy-and-enlarged-spleen Hi all. An 18 month old FE rat presented to me 2 weeks ago with a generalised lymphadenopathy. The owner declined FNA or biopsy and elected to try a course of antibiotics. I prescribed 50mg synulox BID. I saw her again a few days ago. She weighs theen-USTelligent Community 10https://www.vetsurgeon.org/thread/114630?ContentTypeID=1Tue, 20 May 2014 08:24:58 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:6458cdf8-b817-46b4-b204-20fb49b983a2CatherineThomas<p>in the BSAVA manual there is mention of lymphoma giving blood leucocyte counts of upto 400,000/ml^3, splenomegaly and possibly hepatomegaly. Under treatment and prognosis it just says prognosis poor.</p> <p>I&#39;ve never done a rat splenectomy but it must be possible. I would have thought that if it has generalised lymphadenopathy there would be little point in doing a splenectomy because the problem is already generalised.</p> <p>I would be thinking of getting FNAs and blood for haematology as the first step.</p><div style="clear:both;"></div>