methylpred vs pred for LP gastritis/enteritis

Re: methylpred vs pred for LP gastritis/enteritis

shanley barber — Thu, 03 Apr 2014 21:38:44 GMT

Sorry- lymphocytic plasmacytic (LP) gastritis and enteritis. And yes she's been on Hills ZD exclusively for two months now, with a small improvement. Shanley

Re: methylpred vs pred for LP gastritis/enteritis

Anthony Todd — Thu, 03 Apr 2014 21:02:37 GMT

[quote user="shanley barber"] LP gastritis and enteritis[/quote]

Sorry, I'm a dinosaur and don't do abbreviations, WTF is it?

Re: methylpred vs pred for LP gastritis/enteritis

Anonymous — Thu, 03 Apr 2014 15:01:40 GMT

how about the immunomodulatory effects of oxytet, mild but may be worth a try? (? +/- niacinamide?).

Re: methylpred vs pred for LP gastritis/enteritis

John Flynn — Thu, 03 Apr 2014 14:56:45 GMT

[quote user="Andrew Kent"]ou could certainly try methylpred, prednisolone is what has traditionally been used in trials [/quote]

I've always wondered why pred is generally used in trials given that anecdotally the inconvenient side effects of methylpred seem to be less?

Re: methylpred vs pred for LP gastritis/enteritis

Andrew Kent — Thu, 03 Apr 2014 13:06:22 GMT

Hi Shanley,

The problem with budesonide in dogs is that it isn't as effective and still leads to suppression of the HPA axis and so there is minimal benefit to big cost of using it.

You could certainly try methylpred, prednisolone is what has traditionally been used in trials but you could give it a go and see. I suspect you may find a similar problem.

Otherwise I would probably try cyclosporine, should be fairly reasonable cost for a small dog. Response rate is slightly lower but would be worth a trial. Another option would be chlorambucil.

But I would second diet as well if you haven't already tried?

Andy

Re: methylpred vs pred for LP gastritis/enteritis

Robin Grimmer — Thu, 03 Apr 2014 12:47:40 GMT

Have you tried a strict exclusion diet? Many cases will respond favourably and can sometimes manage with diet alone. Budesonide can be used as it's metabolised by the liver, so minimal systemic side effects.