Alternative forms of carbimazole

Re: Alternative forms of carbimazole

Martin Atkinson — Wed, 09 Apr 2014 09:31:13 GMT

[quote user="Thomas Johnson"]Interesting, but would it not be possible that the methimazole has been abdorbed and the dye left on the skin surface to be spread over its coat?[/quote] I guess someone would have to take a sample of the residue and see if there is any active ingredient to prove that one.

Re: Alternative forms of carbimazole

Thomas Johnson — Wed, 09 Apr 2014 09:23:56 GMT

[quote user="Martin Atkinson"]

I asked Carmel Mooney some questions about this at BSAVA congress after her presentation on feline hyperthyroidism. It seems that she has little experience in using the gel because she was not aware that it was available in the UK from Summit (she is at UC Dublin). However, she did say that she'd heard/read about someone who put some dye in the gel and found that it got everywhere - the cat groomed it off and it went all over its coat and possibly the environment. So it appears that contrary to theory it may be only working in part by trans-dermal absorption and may be, at least partly, absorbed orally or not at all if the cat is spreading it all over the place. This may explain why the cat I was treating wasn't responding well to it.

[/quote]

Interesting, but would it not be possible that the methimazole has been abdorbed and the dye left on the skin surface to be spread over its coat?

Re: Alternative forms of carbimazole

Martin Atkinson — Wed, 09 Apr 2014 08:59:53 GMT

[quote user="Sarah Keir"]

Is no-one else worried about such a potent drug causing environmental contamination, even in the home of the owner. What about kids stroking the cat? The cat will groom it off and spread it everywhere. Do you get clients to sign off licence forms?

Sarah

[/quote]I asked Carmel Mooney some questions about this at BSAVA congress after her presentation on feline hyperthyroidism. It seems that she has little experience in using the gel because she was not aware that it was available in the UK from Summit (she is at UC Dublin). However, she did say that she'd heard/read about someone who put some dye in the gel and found that it got everywhere - the cat groomed it off and it went all over its coat and possibly the environment. So it appears that contrary to theory it may be only working in part by trans-dermal absorption and may be, at least partly, absorbed orally or not at all if the cat is spreading it all over the place. This may explain why the cat I was treating wasn't responding well to it.

It is then obviously not only children we need to be worrying about but any sexually active woman of child bearing age!

Re: Alternative forms of carbimazole

Darren Long — Tue, 08 Apr 2014 19:37:37 GMT

I use this gel frequently in feline practice and owners love the ease of administration, after obviously trying the licensed forms of thyroid medications first. I was told that risk to the environment of using this gel is negligible especially since it is absorbed rapidly across hairless skin, however research into this field may be needed. When giving out this medication i always get the owner to sign a disclaimer form, tell them to wear latex gloves and would advise against its use if young children lived in the household.

Ive yet to have any cat that has failed to stabilise on the gel and not encountered a cat yet that refuses its application….in comparison to a pill anyhow

Summit are a very feline friendly company compounding many drugs i use into feline-sized tablets making mine and owners lives much easier.

Re: Alternative forms of carbimazole

Linda Filshie — Wed, 26 Mar 2014 22:50:34 GMT

I was reading a cat forum where a US owner said that their compounding pharmacy offered a flavoured methimazole liquid (or actually several different flavours) so it's certainly possible but I don't know if Summit does anything like that.

Re: Alternative forms of carbimazole

Sarah Keir — Wed, 26 Mar 2014 17:10:53 GMT

Sarah

Re: Alternative forms of carbimazole

Virginia Campbell — Tue, 25 Mar 2014 19:35:12 GMT

We have a few cats on the Summit transdermal gel and they are doing well....just as good for control as Vidalta in our (albeit limited) experience.

Re: Alternative forms of carbimazole

ChrisBVSc — Tue, 25 Mar 2014 15:04:48 GMT

Thanks for the replies, the gel sounds like it's worth a go for this cat - owner can't pill it, doesn't want surgery or I131, doesn't want to use y/d as multi-cat household & won't be practical. The cat has been on vidalta for a couple of months and the T4 has been well controlled until recently, but tableting in any way possible has been a nightmare since the start & has progressively become more difficult.

Re: Alternative forms of carbimazole

Martin Atkinson — Tue, 25 Mar 2014 10:10:29 GMT

I've had a cat on transdermal methimazole. Its owner cant' pill it, it won't eat Y/D, she didn't want a bilateral thyroidectomy because a previous cat was the one that went chronic hypocalcaemic, and she can't afford radio-iodine therapy. The limitation was how much you can physically apply. Its T4 was 309 before therapy we got it down to 190 with the gel using both pinnas but could get it no lower because she could not apply any more gel. She has now bitten the bullet and its gone for radio-iodine!!

Re: Alternative forms of carbimazole

Busybee — Mon, 24 Mar 2014 18:24:30 GMT

Just put a newly diagnosed cat on this transdermal gel so will see if it works. Is pricey though - with a 50% mark up, makes it ~£45 per 30 days.

Re: Alternative forms of carbimazole

Marie Kubiak — Mon, 24 Mar 2014 16:36:15 GMT

Hi,

have been talking to summit about this today and they have been really helpful, the information they gave me is:

"Our Methimazole Transdermal Gel costs £18 (+ VAT) and is supplied as 3 x 1ml syringes (50mg/ml) which we base on a thirty day supply (5mg/0.1ml). Orders placed before 3pm will be delivered the following working day. Orders under £50 incur a £6 shipping fee, over £50, shipping is free."

Marie

Re: Alternative forms of carbimazole

ChrisBVSc — Mon, 24 Mar 2014 11:58:06 GMT

Thanks Emma, methimazole will do!

Re: Alternative forms of carbimazole

emma_j — Mon, 24 Mar 2014 11:42:47 GMT

Transdermal methimazole is available from Summit, but not heard of a transdermal carbimazole.