Histiocytic Colitis

Re: Histiocytic Colitis

Richard Carter — Mon, 17 Mar 2014 15:40:47 GMT

When it came to breed disposition, the current idea is that these breeds/ individuals are lacking something in their immune system which can differentiate pathogenic from commensual git flora so there is no attempt to produce an immune response and so one is dealing with an immuno-compromised patient hence the blasting with serious antibiotics. No idea what happens when you stop antibiotics though as presumably the infection will just re-establish itself again if it is a genetic problem.

Re: Histiocytic Colitis

John Flynn — Sat, 15 Mar 2014 16:32:22 GMT

[quote user="Laura Smith"]Recently diagnosed an 8month old dog with histiocytic colitis via biopsies. What would you treat it with given enfrofloxacin shouldn't be used in such a young dog?[/quote]

In theory at least, you could do mucosal culture and sensitivity testing (prefarably with MICs) to see what antbiotics might be appropriate?

Otherwise santibiotic choice seems to be based on empicical E.coli sensitivity, macrophage penetration and previous antibiotic usage for the patient.

Chloramphenicol might be an appropiate alternative from the point of view of trying to avoid encouraging FQ resistance, but not really any better from a safety profile which I think is what you are more interested in...

Other drugs that could achieve the aims (in theory) are rifampicin, clarithromycin, azithromycin and florfenicol (probably not any more responsible than a FQ), TMPS and tetracyclines (may be resistance issues already in play).

Re: Histiocytic Colitis

John Flynn — Sat, 15 Mar 2014 15:15:26 GMT

[quote user="Richard Carter"]Histopath results vary according to pathologist[/quote]

Was he saying that he didn't consider histiocytic ulcerative colitis (HUC) in a young boxer as a distinct disease entity?

[quote user="Richard Carter"]

1. Start all chronic enteritis with fenbedazole 50mg/kg for minimum 5 d regardless of giardia results.

2. dietary trial

3. antibiotic trial - Apparently the Americans prefer to start with tylosin 10 - 15mg/kg tid but oxytet at 20mg/kg tid or metronidazole 10mg/kg bid also used.

4. Anti-inflamm/ immunosuppressive - pred/ sulphasalazine etc

[/quote]

Was this the same approach for HUC?

Genuinely interested as I think that might be the same Simpson who was part of the start of this craze for treating HUC with FQ's?

I understand the original post refers to a reported improvement with FQ use in these cases (e.g. http://www.degruyter.com/view/j/pjvs.2013.16.issue-1/pjvs-2013-0028/pjvs-2013-0028.xml)

I don't know enough about these things to know if this is sensible or not, but I would feel vindicated to give an 8 weeks course of enrofloxacin in a young boxer with HUC that was not responding to dietary mangament and fenbendazole etc. At least until presented with a reasoned alteranative.

I wouldn't be worried about FQ side effects on cartilage in such a dog personally.

Re: Histiocytic Colitis

Richard Carter — Sat, 15 Mar 2014 11:48:31 GMT

boxer by any chance?

At CPD East of England December 13 Kenny Simpson discussed IBD some length - take home message was:

Histopath results vary according to pathologist

hypo-proteinaemia more important as px than type

1. Start all chronic enteritis with fenbedazole 50mg/kg for minimum 5 d regardless of giardia results.

2. dietary trial

3. antibiotic trial - Apparently the Americans prefer to start with tylosin 10 - 15mg/kg tid but oxytet at 20mg/kg tid or metronidazole 10mg/kg bid also used.

4. Anti-inflamm/ immunosuppressive - pred/ sulphasalazine etc

good luck

Re: Histiocytic Colitis

Anthony Dennison — Thu, 13 Mar 2014 12:41:16 GMT

What breed of dog is it? Depending on the size of the dog will it not have finished growing by now so will be ok for FQs?