Proteinuria in a 5 yr old ME cross breed

Re: Proteinuria in a 5 yr old ME cross breed

Sara Ramsey — Wed, 05 Mar 2014 08:03:01 GMT

Thanks to all for taking the time to reply. Very helpful.

Re: Proteinuria in a 5 yr old ME cross breed

Rory Bell — Mon, 03 Mar 2014 23:10:25 GMT

I'm afraid my reply is a little limited due to lack of specifics. The main differentials for what you describe are:

a) non specific variation is BUN and creatinine concentrations (a difference in a single unit determined whether a patient is 'azotaemic' or 'non azotaemic' and this is not necessarily clinically significant)

b) a good response to benazepril and diet

c) resolution of a previously diagnosed acute kidney injury

In addition, we do not know what influence the pyuria and sperm will have had on the UPC (they will have had some). So what we need is:

Urinalysis, UPC, sediment exam and a urine culture

Blood pressure

renal profile (BUN, creatinine, Na, K, PO4, calcium, albumin) (especially if not done recently)

1) If all of the above are negative / normal, then discontinue the k/d and benazepril, and retest again in 2-3 weeks time

2) if any of the above are abnormal, particularly investigate / treat as appropriate!

Apologies, this reply is probably a bit vague but feel free to get in touch with any results!

all the best

rory

Re: Proteinuria in a 5 yr old ME cross breed

Yantha Smyth — Mon, 03 Mar 2014 23:06:35 GMT

+1 for blood pressure. I think the dose for benazepril for proteinuria can be increased to bid if necessary. From memory the lower protein diet is supposed to be better for proteinuria dogs because the protein itself can be further damaging to the nephron. Omega fatty acids too? Less food!

Re: Proteinuria in a 5 yr old ME cross breed

Stephen Courtney — Mon, 03 Mar 2014 22:33:47 GMT

If he cannot concentrate his urine and has proteinuria then that suggests tubular damage - but given that the azotaemia has resolved perhaps it is stable.

I worry about giving low protein diets to dogs with significant proteinuria, and now he is non azotaemic personally i wouldn't carry on with the KD, which is pretty fattening.

But I would recommend you get the BP measured - a LOT of these dogs are hypertensive, and dealing with that extends life and reduces morbidity.