Treating demodex with pro meris duo

Re: Treating demodex with pro meris duo

Charlie Lyon — Tue, 18 Mar 2014 19:41:59 GMT

We use oral ivermectin off licence - oramec - works really well, obviously not in Collies and other sensitive breeds but so far not had it fail if aludex\advocate don't do the trick

Re: Treating demodex with pro meris duo

Robin Grimmer — Tue, 18 Mar 2014 17:31:06 GMT

Apparently now treatment of choice is daily milbemycin. We don't have milbemycin on its own so you have to use Milbemax. Works out very expensive though.

Re: Treating demodex with pro meris duo

Dan Pan — Tue, 18 Mar 2014 17:24:19 GMT

I used ivermectin on a generalised demo patient, side effect did occur (Head wobbling). Had to keep lowering the dosage (Much lower than the protocol), other than that she has fully recovered.

The owner's husky was bleeding all over the place with a fever from secondary infection.

Re: Treating demodex with pro meris duo

Mark Holmes — Thu, 20 Feb 2014 23:39:39 GMT

[quote user="Simon Tai"][quote user="Anthony Dennison"]

[quote user="Simon Tai"]Cert VD[/quote]

Sorry, always make me snigger when I see this. Such a child.

[/quote] It used to be a cert SAD. !

[/quote] I have used oral ivermectin as above rising dose - stop immediately if they seem drunk.

Re: Treating demodex with pro meris duo

Simon Tai — Thu, 20 Feb 2014 22:47:29 GMT

[quote user="Anthony Dennison"]

[quote user="Simon Tai"]Cert VD[/quote]

Sorry, always make me snigger when I see this. Such a child.

[/quote] It used to be a cert SAD. !

Re: Treating demodex with pro meris duo

Anthony Dennison — Wed, 19 Feb 2014 18:22:44 GMT

[quote user="Simon Tai"]Cert VD[/quote]

Sorry, always make me snigger when I see this. Such a child.

Re: Treating demodex with pro meris duo

Simon Tai — Wed, 19 Feb 2014 17:37:33 GMT

I always start off at 200ug/kg p/o daily for the first week, increasing to 400ug/kg for the second then 600ug/kg thereafter. I usually have good results if kept on for 2 months after negative skin scraping. The only case where I've seen side effects was in an aged Westie with Cushings disease where he trembled a lot and occasionally fell over !Simon Cert VD

Re: Treating demodex with pro meris duo

Anthony Dennison — Wed, 19 Feb 2014 12:04:44 GMT

One of our vets is doing her CertAVP with a dermatology biased, she's been very helpful with it all. Starting off at a low dose and increasing slowly over the first 5 days usually reduces the risks of major side effects, and the owner is given a list of things to look out for before maximum does is reached.

Re: Treating demodex with pro meris duo

Anonymous — Wed, 19 Feb 2014 10:59:57 GMT

[quote user="Anthony Dennison"]Do many people use oral ivermectin off licence? I've found it to be very effective.[/quote]

same here but its a bit scary with the potential side effects. only used it a couple of times when pro meris wasnt working but it dropped the demodex numbers very quickly.

Re: Treating demodex with pro meris duo

Anthony Dennison — Wed, 19 Feb 2014 09:05:30 GMT

Do many people use oral ivermectin off licence? I've found it to be very effective.

Re: Treating demodex with pro meris duo

David Mills — Mon, 17 Feb 2014 18:45:33 GMT

We see a fair bit of junior demodex here, and found promeris worked well when used q2w - in fact, almost too well as Neil says, many clients don't come back for the follow up after the first couple of treatments. Great shame it's going off the market. May be teaching to suck eggs but found it to be far more effective when put along spine not just back of neck.

With a client base that struggle to keep post-op appointments for stitches out (we had a cat in the other day that had had nylon sutures in for 4 months), and sometimes struggle to even wash themselves weekly, I have grave concerns about compliance with aludex bathing. But then again, I'm not sure daily ivermectin would be any better. At least with promeris you could tell them to come back every 2 weeks and if/when they did, could be sure it had been applied. Ho hum.

Re: Treating demodex with pro meris duo

Simon Tai — Mon, 17 Feb 2014 14:43:06 GMT

I went to NAVC a couple of years back and one of the dermatologists suggested using it every 2 weeks. However, they did note an occasional pemphigus type reaction when used at this frequency. I believe it has now been discontinued over there too . I used it on a couple of cases of generalised demodicosis. Sadly one was a lovely 2 year old Rottie which developed an untreatable non regenerative anaemia/primary bone marrow issue whilst on treatment. Didnt use it again after that.

Re: Treating demodex with pro meris duo

Bob Russell — Mon, 17 Feb 2014 13:49:30 GMT

We always end up using Aludex!

Re: Treating demodex with pro meris duo

Rob Loxley — Mon, 17 Feb 2014 13:46:41 GMT

If the client completely ignores your instructions and pours the Aludex on neat, they go really quite sleepy... The only time I've needed to use antisedan!

Certifect also has amitraz so might be an option - off label and less amitraz than promeris duo however - however I've always had best results with Aludex

Re: Treating demodex with pro meris duo

karen jones — Mon, 17 Feb 2014 13:39:02 GMT

[quote user="Martin Atkinson"]

[quote user="karen jones"]Do warn them about possible sedation , I've had two dogs now I've had it give anti sedan to as they were so sedated they couldn't walk!

[/quote] I'm a bit confused here! Are you talking about Aludex or Pro-Meris causing sedation? And how does Antisedan work in this scenario given it is an Alpha 2 antagonist - am I missing something?

[/quote] Promeris causes sedation and the data sheet says to reverse with antisedan.

Re: Treating demodex with pro meris duo

Bob Russell — Mon, 17 Feb 2014 11:22:51 GMT

[quote user="Martin Atkinson"]

[quote user="karen jones"]Do warn them about possible sedation , I've had two dogs now I've had it give anti sedan to as they were so sedated they couldn't walk!

[/quote] I'm a bit confused here! Are you talking about Aludex or Pro-Meris causing sedation? And how does Antisedan work in this scenario given it is an Alpha 2 antagonist - am I missing something?

[/quote]

Both products can cause sedation. Yes, it can be counteracted by antisedan. Sedation seems quite common with promeris duo.

Re: Treating demodex with pro meris duo

Martin Atkinson — Mon, 17 Feb 2014 11:05:51 GMT

[quote user="karen jones"]Do warn them about possible sedation , I've had two dogs now I've had it give anti sedan to as they were so sedated they couldn't walk!

[/quote] I'm a bit confused here! Are you talking about Aludex or Pro-Meris causing sedation? And how does Antisedan work in this scenario given it is an Alpha 2 antagonist - am I missing something?

Re: Treating demodex with pro meris duo

Bob Russell — Mon, 17 Feb 2014 09:10:03 GMT

Being withdrawn from the market. Stock not being replaced. I will be sorry to see it go.

We used it very successfully for big guns tick problems. Not brilliant results with demodex here!

We have a few very short dated (April 14) M/L if anyone wants it for the cost of posting!

Re: Treating demodex with pro meris duo

Thomas Johnson — Mon, 17 Feb 2014 08:43:12 GMT

[quote user="karen jones"]Do warn them about possible sedation , I've had two dogs now I've had it give anti sedan to as they were so sedated they couldn't walk! It is a spot on I like for mange a nd ticks. Also it doesn't smell nice either

[/quote]

It smells of eucalyptus. I've had good results with it in the past for demodex, but it is going out of production, I tried to order the 10-25kg size a couple of weeks ago and Henry Schein have run out.

Re: Treating demodex with pro meris duo

Bibs — Sun, 16 Feb 2014 09:37:01 GMT

The two PDSAs I've been working in over the past year use pro meris as a first line also. The impression I get is that they are pleased with how it works. They also use it monthly. When I started a dog on it last month I found out that its not being made any more so if you don't already have a course in stock that might be an issue.

Re: Treating demodex with pro meris duo

karen jones — Sun, 16 Feb 2014 07:46:24 GMT

Do warn them about possible sedation , I've had two dogs now I've had it give anti sedan to as they were so sedated they couldn't walk! It is a spot on I like for mange a nd ticks. Also it doesn't smell nice either

Re: Treating demodex with pro meris duo

Yantha Smyth — Sat, 15 Feb 2014 22:08:49 GMT

Thanks! The client is cost concerned, though the pro meris works out about the same. Her main reason for not wanting to use it was the smell, and doing the treatments, and negative things she had heard from other people about it....she wants to try pro meris first but if it fails she will reconsider. Compliance with the spot on shouldn't be a problem as she is quite open to the idea of using it as an ongoing flea and tick control anyway. Fingers crossed! Fortunately I did warn her it could look worse before it improves, and she has antibiotics for a couple of weeks too.

Re: Treating demodex with pro meris duo

Neil Wheadon — Sat, 15 Feb 2014 21:56:36 GMT

The PDSA that I work in uses this routinely for Demodex, monthly treatment and they find that it works very well. The hassle they have is that you need extended treatment and with the dogs looking so much better after 2 treatments the clients don't come back.

One really important point. After the first application many dogs look worse and itch for a few days. The first case I saw I thought that it wasn't working and that it was rapidly spreading demedecosis. So it's a case of client re-assurance.

The clinic see lots and lots especially Staffies, and are pleased with the results, though I think ease of use and initial client complience must be a factor.

Neil

Re: Treating demodex with pro meris duo

emma o'connor — Sat, 15 Feb 2014 20:49:12 GMT

Unfortunately I've found most cases of generalised demodecosis don't respond well to the spot ons. However I can relate to owners that are reluctant to use aludex first line. Promeris only has a licence for monthly use and I'm not familiar using it more often. However, Advocate does have a licence for weekly application to treat demodex. I've had mixed responses to this and the ones that have done ok have been the less severely affected dogs. Out of interest why have they declined to use aludex? If it's based on cost they could well end up spending more using the alternatives as it may take much longer to get remission.