https://www.vetsurgeon.org/f/clinical-questions/17866/ivermectin-hepatotoxicity Hi, I&#39;m currently treating some juvenile capybara with very severe acariasis - suspected secondary to immunosuppression associated with significant husbandry deficits. All are very thin despite eating well and the weakest died 1wk after the firsten-USTelligent Community 10https://www.vetsurgeon.org/thread/107564?ContentTypeID=1Sun, 09 Feb 2014 17:48:20 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:3ad59e54-79d6-4d12-be76-c662c088b479Mark Hedberg<p>[quote user=&quot;Marie Kubiak&quot;]</p> <p>Thanks Mark, I was expecting evidence of food deprivation but the pathologist didn&#39;t seem to think this was the cause. Would have been simpler that way!</p> <p>[/quote]</p> <p>Interestingly there was a post on here not long ago about 2 different pathologist giving 2 wholly different interpretations of the sample; can you ask a second opinion from the company, explaining the background of the case?</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/107560?ContentTypeID=1Sun, 09 Feb 2014 16:37:18 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:2e71bfd4-58a5-4960-8edb-959b998cb798Marie Kubiak<p>Thanks Mark, I was expecting evidence of food deprivation but the pathologist didn&#39;t seem to think this was the cause. Would have been simpler that way!</p> <p>Mariette, I certainly can&#39;t rule out liver issues as the initial factor, leading to mite infestation possibly compromised further by husbandry. It&#39;s incredibly frustrating not knowing what caused the start of problems and more specifically the liver damage. I am assuming the others (and the adults) have been exposed to the hypothetical toxin too and am worried we&#39;re just waiting for these animals to decline and withholding treatment (albeit for mites, liver disease or euthanasia) means they are suffering.</p> <p>I&#39;m glad I haven&#39;t had a dozen replies telling me that ivermectin is clearly the cause, and feel less responsible for the situation but still can&#39;t help but feel bad about the animals.</p> <p>Marie</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/107535?ContentTypeID=1Sun, 09 Feb 2014 12:13:55 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:52f8a817-5d74-4cf0-b040-ea0ad497de35mariette asselbergs<p>Marie, have you considered the hepatic cirrhosis being a factor in this one suffering from sarcoptic mane? Lowered general resistance etc? The cirrhosis was obviously present before you treated it.</p> <p>Mariette</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/107498?ContentTypeID=1Sat, 08 Feb 2014 20:44:23 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:29a5f97f-4054-4494-a50e-4457861ff40dMark Hedberg<p>Actually, here&#39;s something more useful:&nbsp;http://www.hindawi.com/crim/hepatology/2013/749169/</p> <p>While that&#39;s a case from a human suffering from anorexia, what about starvation-induced liver damage? (You mentioned the acariasis was secondary to poor husbandry.)</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/107495?ContentTypeID=1Sat, 08 Feb 2014 20:33:41 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:40be5f98-3cc3-4e4b-bc83-ddcbeb6f9b0bMark Hedberg<p>I love it when owners decide they know better than specialists...good luck with them!</p><div style="clear:both;"></div>