Tranexamic acid in vet medicine

RE: Tranexamic acid in vet medicine

Lindsey Edwards — Wed, 12 Jul 2017 18:27:29 GMT

I spay a number of rescue greyhounds at all stages of heat cycle, don't give routinely unless a history of bleeding is disclosed but will add if appears to be in recent heat/friable, any moderate operative bleeding or any post-op dripping of wound and continue TID x48hours (extend to 24hours after no bleeding if persisting). Would start with IV if concerned and continue with oral once eating/no cannula. Would use in <5% of greyhound surgeries (including spays and amputations) - not common to need it but very helpful to have!

RE: Tranexamic acid in vet medicine

Catriona MacIntyre — Sun, 09 Jul 2017 18:31:48 GMT

Just realised someone booked in a greyhound spay for next week and have been consulting Dr Google.

Do you always use the injection, or can you give a course of tablets perioperatively? Some of the abstracts talked about the injection being used as an emetic.

RE: Tranexamic acid in vet medicine

Beats — Tue, 16 Feb 2016 16:15:42 GMT

[quote user="grumpyoldman"]are whippets involved as well ,we have lots of whippets ,and they also seem to bruise a lot post amputation, mastectomy when you think about it. [/quote]

I believe that anecdotally whippets have been mentioned as having suspected fibrinolytic issues on occasions also as well as greyhounds, but i don't have a source for that and dont' want to start a spurious rumour either!

RE: Tranexamic acid in vet medicine

Lindsey Edwards — Tue, 16 Feb 2016 13:29:14 GMT

I have used in a number of breeds, no bleeds have progressed to needing major intervention and have not identified any adverse events - I'd rather use than withhold

RE: Tranexamic acid in vet medicine

grumpyoldman — Mon, 15 Feb 2016 23:44:43 GMT

does this just include greyhounds or are whippets involved as well ,we have lots of whippets ,and they also seem to bruise a lot post amputation, mastectomy when you think about it.

RE: Tranexamic acid in vet medicine

Virginia Campbell — Mon, 15 Feb 2016 22:32:12 GMT

I haven't seen this in greyhounds but we don't have many in the practice. We have some though, and a good smattering of lurchers (does it happen in lurchers and other sighthounds or just pure greys?) so I'd like to get some in...strikes me as the kind of thing that you suddenly need on a Saturday afternoon. Do you use oral or injectable stuff and how long do you continue after the event?

RE: Tranexamic acid in vet medicine

Virginia Campbell — Mon, 15 Feb 2016 22:31:45 GMT

RE: Tranexamic acid in vet medicine

Lindsey Edwards — Fri, 12 Feb 2016 22:44:24 GMT

I don't use routinely but add at first sign of 'delayed post op bleeding' in greyhounds and they seem to halt at that. Have used in a few other dogs with clotting queries and have not had any adverse events or encountered any prolonged bleeding episodes. I don't like being without it

RE: Tranexamic acid in vet medicine

Beats — Fri, 12 Feb 2016 20:05:25 GMT

[quote user="Tom Ward"]tranexamic acid (cyklokapron). Is anyone using these prophylactially post-surgically in greyhounds??[/quote]

After seeing a greyhound amputation for osteosarcoma go purple and die a few years ago, I vowed I would use prophylactically on next case... but haven't done one since!

Dave

RE: Tranexamic acid in vet medicine

Tom Ward — Fri, 12 Feb 2016 14:53:59 GMT

Bumping this topic after a few years!

There's an article in this week's vet-times about 'Delayed Postoperative Bleeding in Greyhounds', which suggests use of tranexamic acid (cyklokapron). Is anyone using these prophylactially post-surgically in greyhounds??

Re: Tranexamic acid in vet medicine

Michael Woodhouse — Wed, 09 Oct 2013 21:54:37 GMT

A wee bit more anecdotal evidence.

I think I'm going to look at getting some in stock. Just the injection for now. Obviously with full informed consent.

Re: Tranexamic acid in vet medicine

Sibylle — Wed, 09 Oct 2013 21:32:29 GMT

My own collie was on it for 9 months, on expert advice! He was diagnosed with a malignant nasal tumour on CT at the age of 16 1/2. Tranexamic acid helped to control his nosebleeds which were profuse at times (blood running from his nose for 5-10mins, rather than just dripping!) Whenever he had a severe bleed, I increased his dose to 25-30mg/kg bid (500mg tablet/collie), it seemed to take about 24hrs to take effect - he'd have 3-4 bad bleeds in 24hrs and then none a few months. Maintained him at half dose, without any noticeable side effects.

I am sure it improved his quality of life considerably, he was remarkably fit and healthy in every other way, but moderately anaemic after an episode of epistaxis. Funnily enough he loved his agility despite his tumour, and still got some clear rounds (only in anysize competitions) just a few weeks before he was put to sleep, so maybe I should have disclosed that his performance was obviously improved by a banned substance

Re: Tranexamic acid in vet medicine

Michael Woodhouse — Tue, 01 Oct 2013 10:59:58 GMT

That's interesting, thanks.

Re: Tranexamic acid in vet medicine

Utlendigur — Tue, 01 Oct 2013 10:58:51 GMT

[quote user="emma_j"]

Quick googling found this - still reading it between consults but thought I'd share so others can too!

http://www.ijvm.org.il/sites/default/files/hexakapron.pdf

[/quote]

"TXA-treated dogs received significantly less units of blood products"

Fewer not less! .......slinks back to Pedant's corner

Re: Tranexamic acid in vet medicine

emma_j — Tue, 01 Oct 2013 09:50:08 GMT

Quick googling found this - still reading it between consults but thought I'd share so others can too!

http://www.ijvm.org.il/sites/default/files/hexakapron.pdf

Re: Tranexamic acid in vet medicine

Michael Woodhouse — Tue, 01 Oct 2013 09:10:18 GMT

[quote user="Mark Hedberg"]That's why it's a banned substance in horse racing, isn't it? [/quote]

Looking for vet uses the only reference was to the naughty gentleman who was struck off on here!

I'm guessing it would have gone through animal trials in the licensing. As Mark points out - seems safe in the horse.............

Re: Tranexamic acid in vet medicine

Mark Hedberg — Tue, 01 Oct 2013 08:43:31 GMT

[quote user="Michael Woodhouse"]

I could see many possible veterinary uses.

[/quote]

That's why it's a banned substance in horse racing, isn't it?

Re: Tranexamic acid in vet medicine

Linda Filshie — Tue, 01 Oct 2013 08:26:22 GMT

It's also routinely given in some (human) orthopaedic ops as part of the pre-med.

But with some of our relatively benign human medicines having such nasty effects in animals I would certainly wait for some clinical trials to be published first!