Switching anti-seizure medications

Re: Switching anti-seizure medications

Adrienne McPartland — Tue, 03 Sep 2013 23:03:27 GMT

As far as i can remember it was a screenshot taken during the pexion webinar which was Boehringer sponsored.

Re: Switching anti-seizure medications

Sammy82 — Tue, 03 Sep 2013 18:49:57 GMT

I just phoned the Boehringer technical advise service to get the chart/instructions on how to change over. The rep (Tim) was very helpful too.

Re: Switching anti-seizure medications

Noweia — Tue, 03 Sep 2013 18:44:20 GMT

Adrienne the chart is a bit blurred and difficult to read - can you remember where you got it?

Re: Switching anti-seizure medications

Anthony Dennison — Tue, 03 Sep 2013 00:36:31 GMT

Yes, but when I ask for advice all they do is tell me what I can use, not a proper program to switch! Bit frustrating.

Re: Switching anti-seizure medications

Hannah Wynne Richards — Thu, 29 Aug 2013 11:03:49 GMT

Does the referralcentre you normally use have a neurologist?

Wynne

Re: Switching anti-seizure medications

Anthony Dennison — Thu, 29 Aug 2013 10:50:43 GMT

I rang Boehringer about using Pexion in Lafora's. They distanced themselves from it because it is only licensed for idiopathic epilepsy and not sure it would do anything for myoclonic jerking.

Re: Switching anti-seizure medications

Adrienne McPartland — Wed, 28 Aug 2013 22:45:55 GMT

Re: Switching anti-seizure medications

Clair Firth — Tue, 13 Aug 2013 18:17:05 GMT

Non-veterinary experience here but my daughter has epilepsy and had myoclonic, as well as tonic-clonic seizures. Keppra worked brilliantly for us! She was on valproic acid for ages and the seizures actually got a bit worse (then they added lamictal, lamotrigine, into the mix and we spent a few weeks in hospital with a serious adverse drug reaction ) Anyway, she was then switched to Keppra and improved almost over night! Not much specific help but Keppra definitely improved myoclonic seizures in our case - my daughter has now been off meds for a year and seizure-free for 3yrs, touch wood, it stays that way!

Re: Switching anti-seizure medications

Anthony Dennison — Tue, 13 Aug 2013 16:56:16 GMT

[quote user="Robin Grimmer"]

Boehringer's new drug Pexion?

[/quote]

It works on GABA receptors, just like phenobarbitone, so I'm not sure it will help with the myoclonic jerking, which is the main problem currently (had no seizures for quite a while).

Re: Switching anti-seizure medications

Robin Grimmer — Tue, 13 Aug 2013 14:11:00 GMT

Boehringer's new drug Pexion?

Re: Switching anti-seizure medications

David Mills — Tue, 13 Aug 2013 13:03:06 GMT

Keppra's great. Takes 24-48h to reach steady serum state. Normally half the pheno dose whilst changing over over 48h. Quite wide range, normally start higher and more frequent initially. Cheap these days as generic - 500mg is around 9p per cap online. Personally hate bromide, large club for a focal problem with side effects lasting for ages.

Re: Switching anti-seizure medications

Anthony Dennison — Tue, 13 Aug 2013 12:56:20 GMT

It may be an idea, but she gets regular pancreatitis flare-ups and has quite sensitive guts. Probably being a bit wimpy avoiding it.

Re: Switching anti-seizure medications

Michael Woodhouse — Tue, 13 Aug 2013 12:34:43 GMT

[quote user="Anthony Dennison"]all available KBr products are too large![/quote]

You can buy 500g pots of potassium bromide from the wholesaler and weigh out as much or as little as you need. Fine under the cascade as licensed meds not suitable size. Really cheap too ~£10.