Ivermectin toxicity in cat

Re: Ivermectin toxicity in cat

Linda Filshie — Wed, 31 Jul 2013 00:00:03 GMT

I can't find anything definitive but would think its to do with it enhancing the effect of GABA (the mechanism of action of avermectins being to increase presynaptic release and enhance post-synaptic binding of GABA, as well as direct GABA agonist effects

Re: Ivermectin toxicity in cat

David Mills — Tue, 30 Jul 2013 23:43:12 GMT

Ivermectin is lipid soluble so would be expected to respond to intralipid (which is soya oil) - it is easily available on prescription, and for some reason is the new fad in ivf women - your nearest hospital will have some (for speed's sake), and its around £15-17 per bag which would easily last 24h. Interestingly, studies have not - yet - documented increased survival rates but have shown less duration of clinical signs (meaning less hospitalisation) when compared to standard supportive treatment. However, this cat has had a high dose so may not respond quickly at all (if at all).

Its all about balance I suppose, and depends on your pricing structure - if you were to make out a prescription and the clients get the intralipid tomorrow this would be the cheapest way of fixing the cat, if fixable (esp if you waived your script fee).

Interestingly, midazolam and propofol would also work for similar reasons, being lipids. Unsure of the veracity of not using benzodiazapenes.

Re: Ivermectin toxicity in cat

Christina Smith — Tue, 30 Jul 2013 23:29:05 GMT

Can't remember the reference but I'm sure I recently read something about treating a cat for permetrin toxicity. I think they used 5-6ml of almond oil/fish oil and some other oil. Gave it IV and was very sucessful. You would need to have this verified as I am a bit hazy.

Re: Ivermectin toxicity in cat

Linda Filshie — Tue, 30 Jul 2013 23:24:05 GMT

Last post on this for now - apparently you should avoid diazepam and other benzodiazepines (just in case you were thinking of giving them)

Re: Ivermectin toxicity in cat

Linda Filshie — Tue, 30 Jul 2013 23:19:22 GMT

Jeepers, just checked the dosage for 0.5% pour on, and it's 1ml/10kg in cattle!

Re: Ivermectin toxicity in cat

Linda Filshie — Tue, 30 Jul 2013 23:16:24 GMT

My trusty handbook of small animal toxicology says "the most important aspect of treatment is to recognise that recovery may be prolonged, taking weeks to months. There is a report of a dog making a full recovery after being comatose for 7 weeks (!)". [exclaimation mark mine] Tx is symptomatic and supportive

CS in cats include disorientation and dementia so could account for the vocalisation.

Re: Ivermectin toxicity in cat

Glenn Hodgson — Tue, 30 Jul 2013 23:15:37 GMT

lipid only 17 quid more than saline i think. could easy save a days hospitalisation? i'd up sell lipid after checking ok to use for this.