Meloxicam dosing in rabbits.

Re: Meloxicam dosing in rabbits.

James Laidlaw — Wed, 08 May 2013 14:12:50 GMT

Ta very much!

Re: Meloxicam dosing in rabbits.

Mark Rowland — Wed, 08 May 2013 14:10:01 GMT

Hope that gets you started . All the best, Mark

Re: Meloxicam dosing in rabbits.

Mark Rowland — Wed, 08 May 2013 14:09:37 GMT

Pharmacokinetics of meloxicam in rabbits after oral administration of single and multiple doses. Am J Vet Res. April 2013;74(4):636-41. Daniel V Fredholm1; James W Carpenter; Butch KuKanich; Micah Kohles 1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506. Article Abstract Objective-To determine the pharmacokinetics of meloxicam (1 mg/kg) in rabbits after oral administration of single and multiple doses. Animals-6 healthy rabbits. Procedures-A single dose of meloxicam (1 mg/kg, PO) was administered to the rabbits. After a 10-day washout period, meloxicam (1 mg/kg, PO) was administered to rabbits every 24 hours for 5 days. Blood samples were obtained from rabbits at predetermined intervals during both treatment periods. Plasma meloxicam concentrations were determined, and noncompartmental pharmacokinetic analysis was performed. Results-The mean peak plasma concentration and area under the plasma concentration-versus-time curve extrapolated to infinity after administration of a single dose of meloxicam were 0.83 μg/mL and 10.37 h•μg/mL, respectively. After administration of meloxicam for 5 days, the mean peak plasma concentration was 1.33 μg/mL, and the area under the plasma concentration-versus-time curve from the time of administration of the last dose to 24 hours after that time was 18.79 h•μg/mL. For single- and multiple-dose meloxicam experiments, the mean time to maximum plasma concentration was 6.5 and 5.8 hours and the mean terminal half-life was 6.1 and 6.7 hours, respectively. Conclusions and Clinical Relevance-Plasma concentrations of meloxicam for rabbits in the present study were proportionally higher than those previously reported for rabbits receiving 0.2 mg of meloxicam/kg and were similar to those determined for animals of other species that received clinically effective doses. A dose of 1 mg/kg may be necessary to achieve clinically effective circulating concentrations of meloxicam in rabbits, although further studies are needed.

Re: Meloxicam dosing in rabbits.

Mark Rowland — Wed, 08 May 2013 14:08:53 GMT

So that article shows that saturation was not reached at 1.5 mg/kg.

Re: Meloxicam dosing in rabbits.

Mark Rowland — Wed, 08 May 2013 14:08:13 GMT

Pharmacokinetics of meloxicam in rabbits after single and repeat oral dosing. Comp Med. February 2006;56(1):63-7. Patricia V Turner1; H Cheng Chen; W Michael Taylor 1Department of Pathobiology, University of Guelph, Guelph, Canada. pvturner@uoguelph.ca Article Abstract We evaluated the pharmacokinetic profile of meloxicam (0.3 and 1.5 mg/kg) given as single and repeated (once daily for 5 d) oral doses to female rabbits (n = 5/group) to define the optimal dose and dosing interval for clinical use. Clinical signs, body weight, and serum chemistry parameters (sodium, potassium, chloride, total protein, urea, creatinine, glucose, alkaline phosphatase, gamma glutamyl transferase, and alanine aminotransferase) were evaluated before and 5 d after dosing to monitor safety at the 2 dose levels in both studies. Plasma samples were collected serially, and concentrations were determined by high performance liquid chromatography. After single oral dosing at 0.3 or 1.5 mg/kg, maximal plasma concentrations of meloxicam were achieved at 6 to 8 h and were 0.14 and 0.3 microg/ml, respectively. Plasma drug levels decreased rapidly to near-undetectable levels by 24 h. There was moderate interindividual variability in plasma meloxicam concentrations with less than proportional increases in peak plasma concentration and area under the concentration curve values at the higher dose after the single and repeat dosing. The elimination half-life was approximately 8 h at both dose levels, suggesting that metabolism was not saturated. Oral clearance of meloxicam is high in rabbits, indicating rapid metabolism and elimination. There was no accumulation of meloxicam when given at 0.3 or 1.5 mg/kg for 5 d, and meloxicam was rapidly eliminated after discontinuation of dosing. Rabbits may require a dose exceeding 0.3 mg/kg given once daily to achieve optimal plasma levels of meloxicam over a 24-h interval.