https://www.vetsurgeon.org/f/clinical-questions/14698/rescue-protocol-for-mast-cell-tumour-patient-on-palladia We have a grumpy &#39;Scotty&#39; dog with multiple mast cell tumours. He has been on Palladia and is close to top dose! Several new tumours have erupted after over a year doing incredibly well! Any ideas? en-USTelligent Community 10https://www.vetsurgeon.org/thread/85139?ContentTypeID=1Fri, 22 Mar 2013 18:41:05 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:4532effd-ba56-4491-b6db-be918de1af31Andrew Kent<p>In people they work their way through the TKI&#39;s so masitinib may be worth a go. Failing that the conventional chemo option would be prednisolone plus vinblastine +/- chlorambucil, assuming surgical removal isn&#39;t possible. Radiotherapy isn&#39;t going to be an option if you have multiple tumour in different areas. <p> Andy</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/85133?ContentTypeID=1Fri, 22 Mar 2013 17:41:44 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:af85929f-2c6c-4d85-bbb3-697f3cd61fe0Martin Atkinson<p>Are you sure your de-novo tumours are mast cells? Even so, it seems that mastinib may not be the holy grail it was once thought to be. Email Gerry Polton at gpolton@ndsr.co.uk or think about radiotherapy.</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/85132?ContentTypeID=1Fri, 22 Mar 2013 17:24:58 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:96f95d85-554f-4f71-9c02-3eb4809c2ffdLaurence Webb<p>Lomustidine?</p> <p>I believe that some oncologists try changing to Masivet (or the other way round if they start on that) if treatment fails, although one I spoke to felt that this made no difference.</p><div style="clear:both;"></div>