Demodecosis treatment

Re: Demodecosis treatment

Gillian Mostyn — Sat, 30 Mar 2013 13:16:12 GMT

I have suggested Martin's answer - can you, as the OP, verify it????? Not sure how it works....

Re: Demodecosis treatment

Bob Russell — Sat, 30 Mar 2013 11:23:42 GMT

How do we mark a thread as answered (being the original poster!)? Lots of good opinions given already so many thanks!

We are using the bottle of Aludex that we managed to snaffle and I will go for milbemycin if the response is poor. I know it is likely to be self-limiting but the dog is pretty uncomfortable (but improving!)

Re: Demodecosis treatment

Sandra Milburn — Tue, 26 Mar 2013 14:02:13 GMT

Apparently Antirobe helps a lot as well. Don't ask me how, but spoke to a dermatologist re a difficult case of Demodex previously and he suggested Antirobe in conjunction with topical Malaseb/ Hibiscrub washes as well. Should be self limiting in a young dog (my case was a 8m old entire SBT), neutering may help.

Re: Demodecosis treatment

Tom Ward — Tue, 26 Mar 2013 08:15:55 GMT

I've had success with milbemax cat in a 30kg ish bullidog after advocate weekly failed and aludex oos, but it worked out at 2 tablets a day which can be prohibitively expensive. Not had any experience with ivermectin but there's no reason why it shouldn't be a viable alternative to milbemycin if costs are an issue, but I agree that a chat about side effects should be had and MDR testing offered.

Re: Demodecosis treatment

Sarah Wheadon — Mon, 25 Mar 2013 22:07:50 GMT

Yes, and the cost of a special import license, then sourcing and Importing from France meant it worked out more costly than the milbemax. Plus, it was a lot of hassle!

Re: Demodecosis treatment

Martin Atkinson — Mon, 25 Mar 2013 19:34:17 GMT

[quote user="Sarah Wheadon"]

We've used milbemax cat in a couple of cases on the advice of some CPD at Bristol Vet School. Cat version is used as much lower dose of praziquantel proportionately. Usual off-label chat and paperwork. Works very well, but always raises an eyebrow with the dispensing nurse!

[/quote] Useful tip but it would make it rather expensive for a big dog. I know I mentioned it earlier in the thread but haven't actually tried it but has anyone tried obtaining the unadulterated form of milbemycin (Interceptor)?

Re: Demodecosis treatment

Sarah Wheadon — Mon, 25 Mar 2013 15:51:08 GMT

Re: Demodecosis treatment

Sarah Keir — Mon, 25 Mar 2013 14:31:11 GMT

One of these? I would like one instead of the usual egg shaped chocolate!

Re: Demodecosis treatment

james herriot lied — Fri, 22 Mar 2013 23:35:19 GMT

Seeing as it's a fairly lipophilic molecule, intralipid ought to have a good effect; ditto for milbemycin/selamectin. Funny, but years ago we used to see loads of ivermectin toxicity in farm collies, and on closer investigation they'd usually had a 'good' dose - 2 or 3 ml for a 25kg dog (usual dose 1ml/50kg in a cow). Wish we'd known about intralipids then.

Re: Demodecosis treatment

David Mills — Fri, 22 Mar 2013 23:11:24 GMT

Interesting, intralipid may be an effective treatment for ivermectin toxicity:

http://onlinelibrary.wiley.com/doi/10.1111/vec.12016/abstract

Re: Demodecosis treatment

Gillian Mostyn — Fri, 22 Mar 2013 20:11:45 GMT

I use ivomec a lot and have just had one border collie owner who wanted the test first - it was negative.

Unfortunately the ivomec was then dispensed incorrectly and the dog received a 10 x overdose. The (elderly) dog went completely blind and very ataxic for a few days but susequently recovered completely just on supportive care.

Re: Demodecosis treatment

Rob Loxley — Fri, 22 Mar 2013 19:40:05 GMT

[quote user="bob lehner"] Just wonder - those of you that do - would you do the gene blood-test thingy routinely - or just for the more at-risk breeds ?[/quote]

I did for an OESD (unsurprisingly, negative) before I put it on ivermec

It's also potentially an issue for doxorubicin, vincristine etc.

Re: Demodecosis treatment

Mark Holmes — Fri, 22 Mar 2013 18:52:55 GMT

I use an increasing dose and stop it at any signs of trouble

Re: Demodecosis treatment

james herriot lied — Fri, 22 Mar 2013 18:40:00 GMT

[quote user="bob lehner"]

Can't say I've used Ivomec a great deal in dogs for this purpose. Just wonder - those of you that do - would you do the gene blood-test thingy routinely - or just for the more at-risk breeds ?

[/quote]

Don't push it myself, but we do have a couple of beardy type breeders (the dogs, not the owners) who do their own cheek swabs and send off to laboklin. Cost about seventy quid.

Has Simon Tappin produced his latest stuff yet - he was starting to find the MDR gene in border collies, and a couple of other breeds.

Re: Demodecosis treatment

bob lehner — Fri, 22 Mar 2013 18:24:39 GMT

[quote user="robloxley"]I was surprised to see some figures on the frequency of MDR1 mutation across different at-risk breeds[/quote]

Can't say I've used Ivomec a great deal in dogs for this purpose. Just wonder - those of you that do - would you do the gene blood-test thingy routinely - or just for the more at-risk breeds ?

Re: Demodecosis treatment

Martin Atkinson — Fri, 22 Mar 2013 16:24:53 GMT

[quote user="Mark Holmes"]The cause doesn't matter so much as what can you do about it - as luck would have it there is this great website available www.naturalhealingsolutions.co.uk where you don't have to be inconvenienced by science or rational thought... Seriously it's totally respectable and not at all a scam as its run by a Veterinary Surgeon[/quote] Have 5 stars from me, if I could have given you 10 I would.

Re: Demodecosis treatment

Glenn Hodgson — Fri, 22 Mar 2013 15:16:35 GMT

[quote user="Carolyn Danbury"]

Must admit I can't remember. Not a collie type though, because I do remember discussing prior to them starting it that we'd all have been very cautious about that!

It's not a reason not to use it, but I do think it's worth a thorough discussion, as with any off-license use. The owners in this case were, understandably, a little upset.

[/quote]

I agree, that is really bad luck.

Re: Demodecosis treatment

Rob Loxley — Fri, 22 Mar 2013 13:55:07 GMT

[quote user="Carolyn Danbury"]Not a collie type though, because I do remember discussing prior to them starting it that we'd all have been very cautious about that![/quote]

I was surprised to see some figures on the frequency of MDR1 mutation across different at-risk breeds

Re: Demodecosis treatment

Mark Holmes — Fri, 22 Mar 2013 13:10:33 GMT

[quote user="patrick murphy"]

typical that it was my longest serving employee, but her working dog got the adult onset, and the only thing, including Aludex and Advocate, was the millbemycin. my query, is that everyone would argue that there must be an immunocompromise somewhere, but after doing every test in the world, excluding CT how do you identify it's cause?

[/quote] The cause doesn't matter so much as what can you do about it - as luck would have it there is this great website available www.naturalhealingsolutions.co.uk where you don't have to be inconvenienced by science or rational thought... Seriously it's totally respectable and not at all a scam as its run by a Veterinary Surgeon

Re: Demodecosis treatment

patrick murphy — Fri, 22 Mar 2013 11:51:14 GMT

Re: Demodecosis treatment

Carolyn Danbury — Fri, 22 Mar 2013 11:12:50 GMT

Must admit I can't remember. Not a collie type though, because I do remember discussing prior to them starting it that we'd all have been very cautious about that!

It's not a reason not to use it, but I do think it's worth a thorough discussion, as with any off-license use. The owners in this case were, understandably, a little upset.

Re: Demodecosis treatment

Glenn Hodgson — Fri, 22 Mar 2013 11:04:28 GMT

[quote user="Carolyn Danbury"]

A colleague of mine did have one case go completely, irreversibly blind on this protocol. Just remember to have a full and frank discussion of the possible side effects!

[/quote] Anecdotes have their place.

Do you know what breed?

Useful information re. Taktic Suzanne, thanks.

Re: Demodecosis treatment

Carolyn Danbury — Fri, 22 Mar 2013 10:41:00 GMT

A colleague of mine did have one case go completely, irreversibly blind on this protocol. Just remember to have a full and frank discussion of the possible side effects!

Re: Demodecosis treatment

Glenn Hodgson — Thu, 21 Mar 2013 20:57:24 GMT

I use daily panomec for injection per os. Works a treat, can't see past it.

Re: Demodecosis treatment

Rob Loxley — Thu, 21 Mar 2013 19:28:49 GMT

[quote user="James Laidlaw"]That was my point - I don't find advocate to be especially stand out effective (usually prefer aludex), BUT, it has a label claim for this condition and if aludex is unavailable, it is the treatment that SHOULD be used under cascade, prior to trying things off cascade.[/quote]

Indeed, and obviously I meant "unimpressed with advocate monthly, seems better weekly".