Demodex

Re: Demodex

David Scarff — Sun, 15 Feb 2009 18:49:24 GMT

Hi, it would seem that the weight of evidence for an additional claim once a product is licensed, is very much less than that for an initial license. I would still favour the approach of using amitrax initially followed by moxidectin or ivermectin if ineffective (with care!). However we do therefore run the risk of using an unlicensed product when one which is licensed but ineffective is available. For this reason, we should all be notifying VMD when products are ineffective, not just when there cause adverse effects.

Re: Demodex

Niall Taylor — Thu, 12 Feb 2009 22:52:29 GMT

[quote user="Ian Mostyn"]If no-one can get Advocate to work, how did it manage to get a license and doesn't that show the licensing system to be at fault?[/quote]

Dunno but I've had little or no success treating demodex with Advocate. Even a case I managed to stabilize on oral avermectins relapsed once the oral meds were stopped and Advocate introduced. Next time I don't think I'd even try using Advocate, I'd be reaching for the Panomec before anything else.

Niall

Re: Demodex

Christopher Tansley — Thu, 08 Jan 2009 20:41:19 GMT

No idea really!

When I have used it it seems to have either failed totally to help or had only marginal improvement.

Have used it AFTER successful treatment with amitraz when they got a few scabs back

In NZ I used it initially at 50mcg/Kg building up by 50 daily to 2-400 mcg/Kg

Re: Demodex

Julian Earl — Thu, 08 Jan 2009 20:17:20 GMT

Many years ago we used to use injectable ivermectin on dogs with demodicosis to great effect, although some would recur after cessation of treatment. We used it at the "standard" 1ml per 50kg in all breeds except those with collie in their name, and treated plenty of dogs with no apparent side-effects.

Re: Demodex

Ian Mostyn — Thu, 08 Jan 2009 17:47:31 GMT

If no-one can get Advocate to work, how did it manage to get a license and doesn't that show the licensing system to be at fault?

Re: Demodex

Laurence Webb — Thu, 08 Jan 2009 09:00:21 GMT

I've similarly had no success with Advocate. I've used Promeris in 1 puppy (so not a chronically affected case) with great success though. If it were chronically affected and wasn't responding to amitraz (or I couldn't get hold of any) I'd probably head towards ivermectin orally but give a low dose to start with to check for toxicity.

Re: Demodex

David Scarff — Wed, 07 Jan 2009 22:46:03 GMT

Ivermectin orally can be very effective at 200-400mcg/kg daily, and is well toerated in most dogs. However as an unlicensed medicine where the commonest side effect (albeit very rare) is death, we should be cautious in its use unless all other options have been tried. I have also had little or no success with Advocate for demodicosis, likewise with Promeris duo.

David Scarff

Re: Demodex

Ian Mostyn — Wed, 07 Jan 2009 16:40:14 GMT

I have used oral ivermectin on a few dogs in the UK with a lot of success. I haven't found Advocate to be much use though.

Re: Demodex

Christopher Tansley — Wed, 07 Jan 2009 13:24:14 GMT

Very delayed reply and probably no longer an issue - sorry - just seen the thread.

In NZ we used ivomec (no amitraz) given either SQ or orally

Would have though dectomax would do a really good job though.

Re: Demodex

David Scarff — Sun, 14 Dec 2008 19:28:14 GMT

Sorry for taking a while to reply: Taktic is useful as a sounce of amitraz, although the concentrate needs to be treated with care (dissolves some plastics, and cannot be measured out in a plastic syringe for example!). Otherwise use the dilution you have correctly calculated, but obviously be aware that this would now represent an unlicensed product in the dog.