PU/PD/PP crossbreed

Re: PU/PD/PP crossbreed

Kate Richardson — Tue, 08 Jan 2013 10:42:55 GMT

Another vote for Cushings but consider more than 1 disease process going on at the same time. All other suggestions good, I would also repeat the ACTH stim, may find different results now some more time has passed. If still drawing a blank with more specific testing for HAC, but still thinking Cushings, consider a trial on Trilostane? There is enough evidence so far to be strongly suspicious and often get a very quick response to treatment.

Re: PU/PD/PP crossbreed

Rajat — Tue, 08 Jan 2013 10:35:56 GMT

I have also had one or two cases that repeatedly tested negative on LDDST/ACTH stims but cropped up positive on the SHAP tests. So if despite your suspicions you cannot prove HAC or rule it out(worth getting at home UCCR?) then SHAP test is worth pursuing....

Re: PU/PD/PP crossbreed

KMurphy — Tue, 08 Jan 2013 09:17:21 GMT

I had a similar case once in a Golden Retriever. We eventually ran a SHAP test to confirm atypical Cushing's, just as you're considering. I don't think you'd be wrong to run the test! It would be worth crossing HAC off the list conclusively before you start looking elsewhere.

Re: PU/PD/PP crossbreed

Glenn Hodgson — Mon, 07 Jan 2013 23:15:19 GMT

I agree, looks and smells like HAC.

Re: PU/PD/PP crossbreed

uhoffjohn — Mon, 07 Jan 2013 22:42:17 GMT

Thaught that might be interesting to read. Otherwise looking at thyroid panel should be worth a shot.

http://avmajournals.avma.org/toc/javma/226/4

Re: PU/PD/PP crossbreed

Busybee — Mon, 07 Jan 2013 22:08:17 GMT

PU/PD/PP, weight gain, panting, lethargy, poor hair quality - my money would still be on HAC. It can be very hard to diagnose precisely and false -ve tests are common. Futher testing could include UCCR (good for ruling HAC out if normal), BAST to assess liver function and fT4 in case you really are concerned about hypothyroidism (what is the heart rate?).