Medication for SMI in bitches

Re: Medication for SMI in bitches

Iain McAllister — Tue, 20 Nov 2012 15:17:48 GMT

thanks

Re: Medication for SMI in bitches

Chris Geddes — Tue, 13 Nov 2012 21:01:28 GMT

Hi Iain. One of our tech team would be happy to discuss the off label use of Suprelorin for this condition if you are interested. 01359 243 243 option 1. Chris.

Re: Medication for SMI in bitches

Rob Loxley — Tue, 13 Nov 2012 13:23:24 GMT

[quote user="Iain McAllister"]Incurin and Enurace together[/quote]

Yes, I'd give it a go

Re: Medication for SMI in bitches

Mark Holmes — Tue, 13 Nov 2012 12:52:51 GMT

The effect of GnRH analogs on urinary incontinence after ablation of the ovaries in dogs

I.M. Richler, M. Hubler, W. Jochle, T.E. Trigg, C.A. piche, S. Arnold.

Theriogenology 60 (2003), 1207-1216

After removal of the ovaries approximately 20% of dogs develop urinary incontinence. Removal of the gonads results in estrogen deficiency and chronic elevation in the production and secretion of FSH and LH. The gonadotrophins may directly or indirectly adversely affect the sphincter function of the urethra. Oestrogen replacement therapy and treatment with sympathomimetics, such as ephedrine or phenylpropanolamine (PPA), are effective only in some of the effected dogs, and many of these subsequently become non-responsive. Since the role of the elevated gonadotrophins has not been elucidated, we used depot preparation of GnRH analogues to down-regulate gonadotrophins once or twice in 13 ovariectomised (ovx), incontinent dogs, which were either refractory to -adrenergics (n=11) or in which -adrenergics were contraindicated (n=2). Dogs were treated with leuprolide, deslorelin, buserelin or triporelin. In 7 dogs treatments with GnRH analogues alone (n=11) resulted in continence for 50-738 days (mean 247). In all dogs excepts one, where GnRH treatments did not resolve the incontinence completely, additional treatment with phenylpropanolamine was successful. With additional treatment of phenylpropanolamine complete continence was restored for 21-367 days (mean 159). All treatments caused long-term reduction of circulating FSH and LH concentrations to very low or undetectable levels. No adverse effects of treatments were observed.

Use suprelorin

Re: Medication for SMI in bitches

Iain McAllister — Tue, 13 Nov 2012 12:38:42 GMT

we thought we would explore medical route first...

...from Willows referral site...

The scientific papers published to date suggest that the prognosis following surgery is the same regardless of the technique used:

50% to 60% become continent
30% to 40% are improved but require some supplemental medication to remain continent
10% to 20% do not benefit from surgery

Re: Medication for SMI in bitches

Michael Woodhouse — Tue, 13 Nov 2012 10:51:26 GMT

How about a colposuspension?