Alternatives to tardak for perianal adenomas

Re: Alternatives to tardak for perianal adenomas

Elizabeth Tuley — Wed, 03 Oct 2012 14:11:28 GMT

[quote user="Virginia Campbell"]

I have used Ypozane several times for BPH, once with associated prostatitis, with good results. Haven't yet used for perianal adenoma as all cases lately have gone for castration, but this is what I would reach for if owner didn't want surgery/ GA risk too high

[/quote]

Seconded.

Re: Alternatives to tardak for perianal adenomas

Virginia Campbell — Wed, 03 Oct 2012 14:08:59 GMT

Re: Alternatives to tardak for perianal adenomas

Clive Ansell — Wed, 03 Oct 2012 13:50:22 GMT

Is it definitely an anal adenoma confirmed by histopathology?

I had a complaint against me several years ago; elderly dog with what looked like a small (0.5cm) anal adenoma booked in for removal and castration. Histology report came back as something else, MCT I think. I was accused of carrying out an unnecessary procedure to make money (Even though the cost of castration inc ga was less than the standard ga fee), and causing additional stress to the dog.

Re: Alternatives to tardak for perianal adenomas

Martin Atkinson — Wed, 03 Oct 2012 13:28:35 GMT

[quote user="Chris Geddes"]

As the product manager for Ypozane for the last three years, I can honestly say that I have not heard of a single complication of its use. I cannot say 100% that there haven't been any worldwide as I am not in the office, but I am pretty confident that there haven't been any in the UK, and we sell quite a lot.

[/quote]Look no further than your own data sheets where it states feminisation in possible adverse reactions - given Ypozane is a synthetic progestogen this is not surprising. However, I'm afraid I specialise in evoking Murphy's law, in terms of: if there is minuscule chance that there will be side effects my patients will get them. For other examples: out of the first 6 cats I gave Metacam for cats to, 3 developed renal failure even though I knew they had no renal issues beforehand as they had been blood tested, and the only dog I've put on Pfizer's long acting NSAID Trocoxil developed life-threatening haemorrhagic enteritis! If you have a new product and you want to test if for side effects before you market it send it to me! .

Re: Alternatives to tardak for perianal adenomas

Stephen Courtney — Tue, 02 Oct 2012 21:19:06 GMT

Chris said it all.

I have had positive experiences using Ypozane to treat BPH in a very expensive GSD stud who still manages to get his bitches in whelp. His breeding days are however over due to other health issues, and his balls are in the bin as a more permanent solution to his BPH now there are no more litters wanted.

Re: Alternatives to tardak for perianal adenomas

Chris Geddes — Tue, 02 Oct 2012 20:04:28 GMT

Martin I am very surprised by your comment and shall be digging out your SAE tomorrow. The mode of action of the product is to prevent the incorporation of testosterone into the prostate (and, apparently, anal adenomas, from field experience) and I have not heard of feminisation occurring before; likewise urinary incontinence, or indeed any other complication. Dogs treated with Ypozane, for example, often continue to sire offspring, as testosterone levels are not affected. Suprelorin is a good "road test" of castration as it removes testosterone but one does not see any feminisation as it does not remove testosterone by providing female hormones to decrease testosterone by negative feedback.

Both products last about 6 months (Suprelorin 9.4mg about 12 months)

To the OP - if you want to chat through the relative merits of both - please call 01359 243 243 and select 1 to speak to one of our advisors during office hours.

Chris

Re: Alternatives to tardak for perianal adenomas

Gillian Mostyn — Tue, 02 Oct 2012 17:06:48 GMT

[quote user="Mark Holmes"]I've generally used suprelorin rather than ypozane. [/quote]

The OP only wanted something fairly short-acting though. if you want something to act permamently then castration would be a better idea.

Re: Alternatives to tardak for perianal adenomas

Gillian Mostyn — Tue, 02 Oct 2012 16:48:40 GMT

[quote user="Martin Atkinson"]plus it is contraindicated in dogs with liver disease[/quote]

erm...not exactly what the data sheet says really! It has no contraindications. However, it does say, under special precautions:

Use with caution in dogs with a history of liver disease, as safety of use of the product in these dogs has not been thoroughly investigated, and as treatment of some dogs with liver disease has resulted in reversible elevation of ALT and ALP in clinical trials.

Doesn't worry me TBH!

Re: Alternatives to tardak for perianal adenomas

Michael Woodhouse — Tue, 02 Oct 2012 16:48:11 GMT

TBH I'd just get on and castrate and do the adenoma under a second GA in a month.

Re: Alternatives to tardak for perianal adenomas

Mark Holmes — Tue, 02 Oct 2012 16:47:37 GMT

I've generally used suprelorin rather than ypozane. Seems to be very effective for BPH, adenomas etc etc.

Re: Alternatives to tardak for perianal adenomas

Gillian Mostyn — Tue, 02 Oct 2012 16:44:28 GMT

yeah - I've found ypozane very useful for these, and BPH, with no side effects seen.

Re: Alternatives to tardak for perianal adenomas

Simon Neuhoff — Tue, 02 Oct 2012 16:23:50 GMT

[quote user="Gillian Mostyn"]

I would have thought ypozane would be a better alternative. Virbac are always happy to discuss these cases - just give their vet advisor a ring.

[/quote]

Have used Ypozane twice to date with these and had great responses with no side effects to date. YMMV.

Re: Alternatives to tardak for perianal adenomas

Martin Atkinson — Tue, 02 Oct 2012 15:57:02 GMT

I have only used Ypozane once: on a nurse's dog with prostatic hypertrophy it caused urinary incontinence and feminisation which took months to resolve so I'm reluctant to use it again plus it is contraindicated in dogs with liver disease - a consideration in a Bedlington? You may well need 2 doses of Tardak anyway so that the cost of the bottle becomes less restrictive. I use Tardak quite frequently as an aid to demonstrating to owners with badly behaved male dogs or those that hump the maiden aunt's knee that castration will not necessarily be the short cut to their inadequate training, or otherwise as the case may be!

Re: Alternatives to tardak for perianal adenomas

Gillian Mostyn — Tue, 02 Oct 2012 12:12:42 GMT

I would have thought ypozane would be a better alternative. Virbac are always happy to discuss these cases - just give their vet advisor a ring.

Re: Alternatives to tardak for perianal adenomas

Bob Russell — Tue, 02 Oct 2012 11:22:38 GMT

See if a neighbouring practice has a bottle open!

We were in a similar situation and hadn't used Tardak in years but decided to charge the owner the cost of the bottle (no mark up) plus VAT. To my surprise a second dog came in a week later needing Tardak for a prostate problem.

Tardak patients can be a little like buses!