Rabbit/Guinea Pig Antibiotic doses

Re: Rabbit/Guinea Pig Antibiotic doses

Martin Atkinson — Thu, 12 Jul 2012 10:12:57 GMT

[quote user="Mark Frost"]For the doses you use are they once or twice daily?[/quote] Well....they're supposed to be twice daily but I find that once daily at the higher dose works OK! Also (and this will open Pandora's Box) I've found Convenia injection works wonderfully well in rabbit abscess that have failed to respond to oral medication. It is contraindicated but I've not had any issues. I suspect its a lot to do with lack of client compliance - you tell 'em to dose twice daily but how many really do it properly?

Re: Rabbit/Guinea Pig Antibiotic doses

Stephen Courtney — Wed, 11 Jul 2012 22:26:49 GMT

I tend to use septrin at 1ml per kg twice a day. i almost never use baytril in small furries as it almost never seems to do any good at all.

I have had good results with weekly injections of depocillin for rabbits ( not other small furries)

I used to use a lot of betadine ( povidone iodine) ointment but alas it seems to have gone off the market. great for treating bunny abscesses as open wounds.

Re: Rabbit/Guinea Pig Antibiotic doses

Rajat — Wed, 11 Jul 2012 19:13:39 GMT

You're very welcome ! Thanks for asking the question too - I learnt something new!

Re: Rabbit/Guinea Pig Antibiotic doses

Mark Frost — Wed, 11 Jul 2012 18:02:38 GMT

[quote user="Rajat"]

I'm a little confused - if peak concentrations are reached , isn't this all that a concentration dependent antibiotic needs to be efficacious?

[/quote]

I agree, although I hadn't researched it further, thanks for those links, thats really useful.

Re: Rabbit/Guinea Pig Antibiotic doses

Rajat — Wed, 11 Jul 2012 17:59:29 GMT

[quote user="Mark Frost"]

[quote user="Michael Woodhouse"]

For flouroquinolones I would always rather give a big dose once daily (concentration dependant killing).

[/quote]

This is what I do, and I remember being taught this at University however concern has been expressed by colleagues that its pharmacokinetics require BID dosing.

[/quote]

I'm a little confused - if peak concentrations are reached , isn't this all that a concentration dependent antibiotic needs to be efficacious?

Fast forward 5 mins later I looked it up (was bugging me!! ) - and as usual the answer is - it depends. Some organisms need very little time (of exposure) to a high concentration of fluoroquinolones, and a low AUC/MIC ratio suffices (Area under curve/min inhibitory concentration). Others (Pseudomonas and most gram-ve aerobes according to the website) require much higher length of time and higher AUC/MIC ratios to be killed

http://www.antimicrobe.org/history/pk-pd%20quint.asp

Found an article on enrofloxacin pharmacodynamics in rabbits(there were a few actually) - but dont have access to full text

http://www.ncbi.nlm.nih.gov/pubmed/1664673

http://www.antimicrobe.org/history/pk-pd%20quint.asp

FWIW, I use enrofloxacin SID in most rabbits/small furries because it is easier to use/give, and hence better compliance

Septrin always bid - Upper half of the dose range (cant remember what it was..)

Cheers

Raj

Re: Rabbit/Guinea Pig Antibiotic doses

Mark Frost — Wed, 11 Jul 2012 17:51:15 GMT

[quote user="Martin Atkinson"]

I work on 5-10mg/kg enrofloxacin with the most practical dose being the deciding factor tending to go for higher doses for smaller sizes so its more measurable but I've seen up to 20mg/kg recommended by some sources, Septrin 15-30mg/kg same rules.

[/quote]

For the doses you use are they once or twice daily?

Re: Rabbit/Guinea Pig Antibiotic doses

Mark Frost — Wed, 11 Jul 2012 16:54:19 GMT

[quote user="Michael Woodhouse"]

For flouroquinolones I would always rather give a big dose once daily (concentration dependant killing).

[/quote]

This is what I do, and I remember being taught this at University however concern has been expressed by colleagues that its pharmacokinetics require BID dosing.

Re: Rabbit/Guinea Pig Antibiotic doses

Martin Atkinson — Wed, 11 Jul 2012 16:52:55 GMT

Re: Rabbit/Guinea Pig Antibiotic doses

Michael Woodhouse — Wed, 11 Jul 2012 16:48:28 GMT

For flouroquinolones I would always rather give a big dose once daily (concentration dependant killing).