Hypereosinophilic syndrome in cats?

Re: Hypereosinophilic syndrome in cats?

amiveson — Tue, 22 May 2012 07:53:04 GMT

Many thanks for the replies - pred certainly helping at the moment with the appetite and demeanour!

Re: Hypereosinophilic syndrome in cats?

Martin Atkinson — Mon, 21 May 2012 09:05:34 GMT

I have a cat currently on therapy for hyper-eosinophilic syndrome. Presented as a chronic GIT case, which had had a presumptive diagnosis of IBD 12 months previously and improved with an exclusion diet. The owner had not continued with this and the cat re-presented in very poor condition (nearly a PTS case), palpable mesenteric LNs and thickened GI tract, biopsies showed IBD but most interestingly (can't recall exact figures) there was a moderately raised granulocyte count and 60% were eosinophils! It responded well to 10mg sid and after a few weeks was clinically normal and eosinohil count was back to normal. Presently maintained on 2.5mg preds alternate days and RCW Sensitivity control duck & rice but hasn't been seen for a while so I don't know if success continues, no doubt I will hear if not. I can't remember if I use it initially as an adjunct in this case, but I have used sucralphate as a stand alone with success in milder cases.

Re: Hypereosinophilic syndrome in cats?

Kate Richardson — Sat, 19 May 2012 13:41:06 GMT

Prednisolone most commonly used- 2-4mg/kg/day. If not responding as well as you would like it may be of benefit to try injectable glucocorticoids such as Depomedrone 4mg/kg im every 2-3 weeks for up to 4-5 treatments and then reduce frequency as sometimes drug absorption is reduced by the gi disease.

Other options- Cyclosporin 7.5-10mg/kg/day for up to 4 weeks, then reduce to lowest effective dose. Absorption of cyclosporin can be variable in cats though making appropriate dosing difficult. (this is from notes form Severine Tasker from Bristol Uni in 2004 and Atopica for cats recently released so worth speaking to drug company). Check FeLV/FIV/toxoplasma serology ideally first.

Chlorambucil and aurothioglucose alternative immunosuppressive treatments.

Hydroxyurea in combo with pred has been used with some success- dose rates vary- 25mg/kg PO 3 times a week. Monitor for myelosuppression, also can get vomiting, anorexia and sloughing of nail beds.

Essential fatty acids may be useful as an adjunctive treatment

If it would help, send me a fax number I can send you a copy of the full notes re Eosinophilic diseases, very comprehensive. Poor prognosis though unfortunately.

Kate