Lymphoma treatment in a Guinea Pig

Re: Lymphoma treatment in a Guinea Pig

Glenn Hodgson — Mon, 05 Jan 2015 19:33:12 GMT

Any further thoughts on l asperagenase in g.pigs?

Thanks

Glenn

Re: Lymphoma treatment in a Guinea Pig

Glenn Hodgson — Mon, 05 Jan 2015 11:03:25 GMT

That was my thought. Seems about as minimally invasive and stress free as we can get.

Re: Lymphoma treatment in a Guinea Pig

Martin Atkinson — Mon, 05 Jan 2015 09:41:28 GMT

The huge advantage of Asparaginase is that it can be inject subcutaneously which must be a major plus in a small animal but I confess to no experience in Gn Pigs.

Gerry should be back on line today so hopefully he will pick this up.

Re: Lymphoma treatment in a Guinea Pig

Glenn Hodgson — Mon, 05 Jan 2015 09:08:26 GMT

I am treating a G.Pig with this just now and am interested if any one has a preference between Cyclophosphamide and L-Asperaginase.

L-Asperagenise is far more economical for us GP's to get hold of of late from chemopet.

Does anyone have a favored protocol for l-asperaginase?

Thank you

Re: Lymphoma treatment in a Guinea Pig

Rob Loxley — Tue, 21 Feb 2012 13:49:36 GMT

We have sourced small size cyclophos from the Specials Lab. Not cheap however...

Re: Lymphoma treatment in a Guinea Pig

Mark Rowland — Tue, 21 Feb 2012 09:11:14 GMT

[quote user="Laurence Webb"]

Can you get one of the 'specials' manufacturers to supply smaller tablets? Can't say I'd fancy splitting tablets myself

[/quote]

A Good point well made . Oh come on who wants to live forever?

Ill ask them next time I speak to them (adds to list). They promised me cisapride liquid this year, Im just glad to have the tablets again.

Re: Lymphoma treatment in a Guinea Pig

Laurence Webb — Tue, 21 Feb 2012 08:57:21 GMT

Can you get one of the 'specials' manufacturers to supply smaller tablets? Can't say I'd fancy splitting tablets myself

Re: Lymphoma treatment in a Guinea Pig

Mark Rowland — Mon, 20 Feb 2012 21:47:11 GMT

Monitoring weight is easiest. Off the top of my head it's cyclo at 10mg/kg po every 10 days and pred 1mg/kg daily. I break the tabs for the client and advise gloves etc. I often give abs as well dt the immunosuppression. Not seen cystitis myself. I'll check the cyclo dose in work tomorrow for you :-)

Re: Lymphoma treatment in a Guinea Pig

KathW — Mon, 20 Feb 2012 20:47:01 GMT

Thank-you Mark. Are the protocols in any papers/books? I'm struggling to fine anything concrete about doses and how to split the tablets (I presume they'd need splitting!)

Would you try and do bloods/blood smears to monitor or that just too tricky . Do you tend to get any side effect such as cystitis.

Apologies for all the questions.

Re: Lymphoma treatment in a Guinea Pig

Mark Rowland — Mon, 20 Feb 2012 19:29:14 GMT

Steroids can be very immunosuppressive in GPs so I would use with caution. I have used steroid/cyclophosphamide combos for these once the diagnosis has been confirmed by histo of a good biopsy. Few weeks to a few months has generally been my experience also.

Goodluck

Re: Lymphoma treatment in a Guinea Pig

KathW — Mon, 20 Feb 2012 18:50:36 GMT

Thanks Niall. I did get to ring a vet today for advice. He was v busy + so rushed on the phone but said he used cyclophasphamide. Sometimes worked well for few weeks to a few months sometimes no response. He couldn't say what protocol he used but did imply he could maybe look up notes on some others he'd used it on if we confirmed it. He did say try and avoid steroids?? Didn't say why.

Re: Lymphoma treatment in a Guinea Pig

Niall Taylor — Mon, 20 Feb 2012 18:31:43 GMT

In lymphomas in other species some will respond extremely well to glucocorticoids for some while - others don't of course and the owner needs to understand that from the start. Unfortunately my daughter's cavey fell into the latter category a few years ago when he contracted the condition.

Niall