https://www.vetsurgeon.org/f/clinical-questions/10444/persistent-dog-haematuria---picture-attached Hi everyone, As my cytology skills are VERY limited, can anyone extract any helpful information from this picture of a dog&#39;s urine sediment? He is a rescued old boy who has had persistent haematuria and the original urine I sent for cytology toen-USTelligent Community 10https://www.vetsurgeon.org/thread/53604?ContentTypeID=1Tue, 24 Jan 2012 12:28:13 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:9be188ce-ce0d-4107-9a31-e39c3a1d5953Richard Fox<p>My thoughts, BTW nice image !</p> <p>Cytology should be an &#39;assessment&#39; of multiple cells. Concentrating on one or two I do not recommend. There are RBC&#39;s so where is the bleeding from? Most often the bladder? Any leukocytes to suggest cystitis? Any bacteria or crystals to explain the haematuria? I would hesitant to completely rule out neoplasia? Any evidence or mural thickening or a polyp? The cells seem to contain crystals - these dont look like stain deposit so? Oxalate urolithiasis can case haematuria?</p> <p>I agree macrophages are not usually identified in urine so prob a degenerate transitional cell. Binucleate cells do not directly indicate neoplasia but I don&#39;t think you can rule this out entirely esp an adenomatous polyp. Binucleated transitional cells are most often superficial cells of the bladder and are infrequently ID&#39;s in cytology preps. The cells do not seem to have a high nuclear to cytoplasmic ratio / nuclear atypia.</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/53589?ContentTypeID=1Tue, 24 Jan 2012 11:35:37 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:4dd139bc-50e3-40ef-a4c8-df3dffa1656eMike Nikolaou<p>I emailed the picture to my lab and they sent me this reply:</p> <p> <span id="yui_3_2_0_1_1327396974027157" style="font-size:11pt;color:#1f497d;"> &quot;The large binucleate cell with eccentric nuclei is likely to be a macrophage. </span> </p> <div id="yui_3_2_0_1_1327396974027184" class="yiv99189283MsoNormal"><span style="font-size:11pt;color:#1f497d;"> &nbsp;</span></div> <div id="yui_3_2_0_1_1327396974027188" class="yiv99189283MsoNormal"><span id="yui_3_2_0_1_1327396974027187" style="font-size:11pt;color:#1f497d;">However it is very unusual to see macrophages in a urine sediment.&nbsp; A less likely possibility is that these are transitional epithelial cells showing atypical phagocytic activity at a site of chronic haemorrhage.</span></div> <div class="yiv99189283MsoNormal"><span style="font-size:11pt;color:#1f497d;"> &nbsp;</span></div> <div class="yiv99189283MsoNormal"><span style="font-size:11pt;color:#1f497d;">Either way, these cells do not support a diagnosis of neoplasia.&quot;</span></div> <div class="yiv99189283MsoNormal"><br /></div> <p class="yiv99189283MsoNormal"><span style="font-size:11pt;color:#1f497d;">Back to the drawing board I suppose.<br /></span></p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/53571?ContentTypeID=1Tue, 24 Jan 2012 09:23:34 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:cb45d141-471c-43a3-aaf9-e5bc3a071413argyro koukouseli<p>hi&nbsp;</p> <p>how was the sample taken?</p> <p>does the dog drip blood detween urination?if yes probably its the prostate</p> <p>did the cbc show anithing abnormal?</p> <p>does the dog poop without effort?</p> <p>by haematuria do you mean redish urine or did you find red blood cells in speciment?also any neutrophils?</p> <p>any chance of dog having an accident ?saw a cat once with persistent haematuria after hit by car,coming from the kidneys</p> <p>my cytology skills are not that good either but it looks like a transitional cell and if there is alot of them variable in size,with variable cytoplasmic to nuclear ratio you can call it a malignancy.</p> <p>make sure there are red blood cells ,that there was no accident check kidneys creatine and by u/s could be kidney tumor,make sure no prostatic cysts or inflammation.if no kindey problem or clotting problem i would castrate and treat wiyh antibiotics&nbsp;</p><div style="clear:both;"></div>